Results 51 to 60 of about 161,334 (315)

Ideal minimal residual-based proper generalized decomposition for non-symmetric multi-field models – Application to transient elastodynamics in space-time domain [PDF]

, 2014
It is now well established that separated representations built with the help of proper generalized decomposition (PGD) can drastically reduce computational costs associated with solution of a wide variety of problems.
BOUCINHA, Lucas, NOUY, Anthony, AMMAR, Amine, GRAVOUIL, Anthony   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Integrability of a Family of Four-Dimensional Quadratic Lotka–Volterra Complex Systems

Axioms
This work addresses the integrability of four-dimensional quadratic Lotka–Volterra systems exhibiting (1:−1:i:−i) resonance by identifying the parameter constraints required for such properties to exist.
Ivan Mastev, Valery G. Romanovski
doaj   +1 more source

A flexible and scalable scheme for mixing computed formation energies from different levels of theory

npj Computational Materials, 2022
Computational materials discovery efforts are enabled by large databases of properties derived from high-throughput density functional theory (DFT), which now contain millions of calculations at the generalized gradient approximation (GGA) level of ...
Ryan S. Kingsbury, Andrew S. Rosen, Ayush S. Gupta, Jason M. Munro, Shyue Ping Ong, Anubhav Jain, Shyam Dwaraknath, Matthew K. Horton, Kristin A. Persson   +8 more
doaj   +1 more source

Artificial life meets computational creativity? [PDF]

, 2009
I review the history of work in Artificial Life on the problem of the open-ended evolutionary growth of complexity in computational worlds.
McMullin, Barry
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Comparison of Computational Intelligence Methods Based on Fuzzy Sets and Game Theory in the Synthesis of Safe Ship Control Based on Information from a Radar ARPA System [PDF]

Remote Sensing, 2019
This article presents safe ship control optimization design for navigator advisory system. Optimal safe ship control is presented as multistage decision-making in a fuzzy environment and as multistep decision-making in a game environment. The navigator’s subjective and the maneuvering parameters are taken under consideration in the model process.
Józef Lisowski, Mostefa Mohamed-Seghir
openaire   +1 more source

Optimization-Based Methods for Nonlinear and Hybrid Systems Verification [PDF]

, 2005
Complex behaviors that can be exhibited by hybrid systems make the verification of such systems both important and challenging. Due to the infinite number of possibilities taken by the continuous state and the uncertainties in the system, exhaustive ...
Prajna, Stephen
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source