Results 71 to 80 of about 3,156,569 (293)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Fractal and FractionalThis work develops a Boundary Element Method (BEM) formulation for simulating bioheat transfer in perfused biological tissues using the Atangana–Baleanu fractional derivative in the Caputo sense (ABC).
Mohamed Abdelsabour Fahmy, Ahmad Almutlg
doaj +1 more source
Modelling Alzheimer’s disease: from past to future
Frontiers in Pharmacology, 2013 Alzheimer’s disease (AD) is emerging as the most prevalent and socially disruptive illness of aging populations, as more people live long enough to become affected. Although AD is placing a considerable and increasing burden on society, it represents the
Claudia eSaraceno +4 more
doaj +1 more source
When, why and how tumour clonal diversity predicts survival
Evolutionary Applications, 2020 The utility of intratumour heterogeneity as a prognostic biomarker is the subject of ongoing clinical investigation. However, the relationship between this marker and its clinical impact is mediated by an evolutionary process that is not well understood.
Robert Noble +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
EnergiesWith the rapid development of hydrogen fuel cell vehicles, the research on the throttling effect of high-pressure hydrogen is crucial to the safety of hydrogen circulation systems for fuel cells. This paper studies the Joule-Thomson coefficients (μJT) of
Mu-Yao Zhou +6 more
doaj +1 more source
Models of Models: A Translational Route for Cancer Treatment and Drug Development
Frontiers in Oncology, 2017 Every patient and every disease is different. Each patient therefore requires a personalized treatment approach. For technical reasons, a personalized approach is feasible for treatment strategies such as surgery, but not for drug-based therapy or drug ...
Lesley A. Ogilvie +5 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Journal of Trial and ErrorPracticing open science can have benefits for the career prospects of individual researchers or labs through higher quality work and increased chances of publication.
Maximilian~Linde +3 more
doaj +1 more source
Cholinergic modulation of cognitive processing: insights drawn from computational models
Frontiers in Behavioral Neuroscience, 2012 Acetylcholine plays an important role in cognitive function, as shown by pharmacological manipulations that impact working memory, attention, episodic memory and spatial memory function.
Ehren L Newman +4 more
doaj +1 more source