Results 71 to 80 of about 23,674,484 (362)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Технічна інженеріяThe paper presents the results of research on the selection of the model of rock massif destruction by explosion of a borehole charge in ANSYS environment with the use of the program complex of engineering analysis AUTODYN, as well as the calculation of ...
О.О. Frolov, M.I. Beltek, T.V. Kosenko
doaj +1 more source
Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives [PDF]
, 2022 Michael A. Colman +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits
Journal of Neuroscience, 2013 Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear.
M. Capogrosso +7 more
semanticscholar +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The Nature of Computational Models
Computing in Science & Engineering, 2023 Computational models lie at the heart of computational science. And yet, few scientists have a clear idea of what a computational model actually is. Is it software? Or an algorithm? How does it relate to mathematical models? What are suitable languages or notations for expressing a computational model in the literature?
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Frontiers in Psychology, 2014 The effects of striatal dopamine (DA) on behavior have been widely investigated over the past decades, with ``phasic'' burst firings considered as the key expression of a reward prediction error responsible for reinforcement learning.
Vincenzo G. Fiore +7 more
doaj +1 more source
Sculpting Computational‐Level Models [PDF]
Topics in Cognitive Science, 2017 AbstractIn this commentary, I advocate for strict relations between Marr's levels of analysis. Under a strict relationship, each level is exactly implemented by the subordinate level. This yields two benefits. First, it brings consistency for multilevel explanations.
Blokpoel, M., Blokpoel, M.
openaire +4 more sources