Results 31 to 40 of about 3,458,417 (246)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Physics education for the 21st century, solving analytically unsolvable differential equations
Frontiers in Applied Mathematics and StatisticsFor nearly three centuries, Newton’s paradigm—modeling physical systems with differential equations and analyzing them with analytic calculus—defined classical physics.
William Flannery
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Physics computational literacy: An exploratory case study using computational essays
Physical Review Physics Education Research, 2019 Computation is becoming an increasingly important part of physics education. However, there are currently few theories of learning that can be used to help explain and predict the unique challenges and affordances associated with computation in physics ...
Tor Ole B. Odden +2 more
doaj +1 more source
, 2007 Fully updated new edition for graduate students and researchers in theoretical, computational and experimental ...
Thijssen, Jos M
core
Computational physics: an introduction
, 1994 Author Franz J. Vesely offers students an introductory text on computational physics, providing them with the important basic numerical/computational techniques.
Vesely, Franz J, VESELY, FRANZ J.
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Nuclear Fusion, 2023 Detailed knowledge of energy exchange between electrons and ions is of fundamental importance for the description of temperature relaxation and also other nonequilibrium physics in Inertial Confinement Fusion (ICF). We present a theoretical model for the
Chengliang Lin +4 more
doaj +1 more source