Results 31 to 40 of about 135,074 (266)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Nuclear Fusion, 2023 Detailed knowledge of energy exchange between electrons and ions is of fundamental importance for the description of temperature relaxation and also other nonequilibrium physics in Inertial Confinement Fusion (ICF). We present a theoretical model for the
Chengliang Lin +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
“Computational Mathematics and Mathematical Physics”—Editorial I (2021–2023)
Axioms, 2023 Based on the papers published in the Special Issue of the scientific journal Axioms, here we present the Editorial Article “Computational Mathematics and Mathematical Physics”, the main topics of which include both fundamental and applied research in ...
Hovik A. Matevossian +1 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
EntropyA univariate stochastic system driven by multiplicative Gaussian white noise is considered. The standard method for simulating its Langevin equation of motion involves incrementing the system’s state variable by a biased Gaussian random number at each ...
Mykhaylo Evstigneev, Deniz Kacmazer
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Physics computational literacy: Programming, modeling, and collaboration at the journeyman level
Physical Review Physics Education ResearchComputation has become an integral part of physics research. However, little is known about how students learn to productively use computation as a tool beyond the introductory level, especially as they transition into physics research. In this study, we
Karl Henrik Fredly +2 more
doaj +1 more source
Quantum physics and computers [PDF]
Contemporary Physics, 1996 27 pages, LaTeX, 8 PostScript figures embedded. A bug in one of the postscript files has been fixed. Reprints available from the author.
openaire +2 more sources