Results 51 to 60 of about 186,255 (315)

Energy deposition and deflection of α particles in hot dense plasmas relevant to inertial confinement fusions

Nuclear Fusion, 2023
Based on the kinetic theory, improved T -matrix models for the continuous-slowing-down and the linear-energy-transfer stopping powers are established at the same level, where multiple scattering effects and the related transverse deflection are accounted
Chengliang Lin, Bin He, Yong Wu, Jianguo Wang   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Computational Materials: Preface

, 2004
10.1016/j.commatsci.2004.04.001Computational Materials Science303-4 SPEC.
Srolovitz, D., Philpott, Michael R., Feng, Y.P., Chen, K., Srolovitz, David, Wu, Ping, Wu, P., Feng, Yuan Ping, Philpott, M.R., Chen, Kan   +9 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Computational Essays: An Avenue for Scientific Creativity in Physics

, 2019
Computation holds great potential for introducing new opportunities for creativity and exploration into the physics curriculum. At the University of Oslo we have begun development of a new class of assignment called computational essays to help ...
Odden, Tor Ole B., Marcos D. Caballero, Odden, Tor Ole, Caballero, Marcos Daniel, Caballero, Marcos D., Tor Ole B. Odden   +5 more
core   +1 more source

Active learning algorithm for computational physics

Physical Review Research, 2020
In large-scale computations of physical problems, one often encounters the situation of having to determine a multidimensional function, which can be numerically costly when computing each point in this multidimensional space is already time-demanding ...
Juan Yao, Yadong Wu, Jahyun Koo, Binghai Yan, Hui Zhai   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Linear analysis of Atwood number effects on shear instability in the elastic–plastic solids

Scientific Reports, 2021
The evolution of shear instability between elastic–plastic solid and ideal fluid which is concerned in oblique impact is studied by developing an approximate linear theoretical model.
Xi Wang, Xiao-Mian Hu, Sheng-Tao Wang, Hao Pan, Jian-Wei Yin   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Nonlinear Dynamics in Computational Neuroscience

, 2019
This book provides an essential overview of computational neuroscience. It addresses a broad range of aspects, from physiology to nonlinear dynamical approaches to understanding neural computation, and from the simulation of brain circuits to the ...

core   +1 more source