Results 41 to 50 of about 33,138 (231)

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

Personalized Network‐Guided Neuromodulation Enhances Human Working Memory

Advanced Science, EarlyView.
A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan, Hongming Li, Camille Blaine, Julie Grier, Ethan Hammett, Almaris Figueroa‐Gonzalez, Sarai Garcia, Romain Duprat, Justin Reber, Joseph Deluisi, Christos Davatzikos, Theodore D. Satterthwaite, Yong Fan, Desmond J. Oathes   +13 more
wiley   +1 more source

Paranoia as a deficit in non-social belief updating

eLife, 2020
Paranoia is the belief that harm is intended by others. It may arise from selective pressures to infer and avoid social threats, particularly in ambiguous or changing circumstances.
Erin J Reed, Stefan Uddenberg, Praveen Suthaharan, Christoph D Mathys, Jane R Taylor, Stephanie Mary Groman, Philip R Corlett   +6 more
doaj   +1 more source

What is Computational Psychiatry Good For?

Biological Psychiatry, 2022
Computational models are often used in psychiatry to identify and measure hidden processes that we hope might have clinical relevance. In other words, they can be useful when answering mechanistic questions. In this commentary we discuss an underappreciated facet of computational approaches; even if they are unable to answer a question, they can be ...
Browning, M, Paulus, M, Huys, QJM
openaire   +5 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Interactive Psychometrics for Autism With the Human Dynamic Clamp: Interpersonal Synchrony From Sensorimotor to Sociocognitive Domains

Frontiers in Psychiatry, 2020
The human dynamic clamp (HDC) is a human–machine interface designed on the basis of coordination dynamics for studying realistic social interaction under controlled and reproducible conditions.
Florence Baillin, Florence Baillin, Aline Lefebvre, Aline Lefebvre, Amandine Pedoux, Yann Beauxis, Denis A. Engemann, Anna Maruani, Frédérique Amsellem, J. A. Scott Kelso, J. A. Scott Kelso, Thomas Bourgeron, Richard Delorme, Richard Delorme, Guillaume Dumas, Guillaume Dumas, Guillaume Dumas, Guillaume Dumas   +17 more
doaj   +1 more source

Trials for computational psychiatry

Nature Computational Science
Psychiatric disorders affect the higher functions of the brain. Motivation, inference, prediction, memoryand perception all fall prey to psychiatric illnesses. Our understanding of these higher functions has been substantially advanced by computational methods over the past three decades.
Quentin JM Huys, Michael Browning
openaire   +3 more sources

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Direct Regioselective para‐Fluorination via I(I)/I(III) Catalysis

Angewandte Chemie, EarlyView.
A direct, para‐selective fluorination by I(I)/I(III) catalysis is disclosed that does not require substrate pre‐functionalization. This strategy leverages the Leonard link inherent to phenylpropanoate and phenylpropanamides to promote a spirocyclization/para‐selective sequence. The C3‐side chain maps onto a range of common drug scaffolds and allows the
Christoph Roblick, Julian D. Bendix, Timothy A. Hilton, Kathrin Bussmann, Constantin G. Daniliuc, Ryan Gilmour   +5 more
wiley   +2 more sources