Results 61 to 70 of about 2,430,102 (287)

Steering in computational science: mesoscale modelling and simulation

, 2003
This paper outlines the benefits of computational steering for high performance computing applications. Lattice-Boltzmann mesoscale fluid simulations of binary and ternary amphiphilic fluids in two and three dimensions are used to illustrate the ...
AR Porter, Chapman S., DeFanti T., Foster I., Foster I., Frisch U., Gompper G., Gonzalez-Segredo N., J Chin, J Harting, Jenness T., Liboff R. L., Love P. J., Love P. J., Ou W., PV Coveney, Reichl L. E., Rothman D. H., S Jha, Schroeder W., SM Pickles, Sued S., Van Wijk J. J.   +22 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Computational reproducibility in computational social science

EPJ Data Science
Open science practices have been widely discussed and have been implemented with varying success in different disciplines. We argue that computational-x disciplines such as computational social science, are also susceptible to the symptoms of the crises,
David Schoch, Chung-hong Chan, Claudia Wagner, Arnim Bleier   +3 more
doaj   +1 more source

MANIFESTO OF COMPUTATIONAL SOCIAL SCIENCE

Mediações: Revista de Ciências Sociais, 2013
The increasing integration of technology into our lives has created unprecedented volumes of data on society’s everyday behaviour. Such data opens up exciting new opportunities to work towards a quantitative understanding of our complex social systems ...
Rosaria Conte, Nigel Gilbert, Giullia Bonelli, Claudio Cioffi-Revilla, Guillaume Deffuant, János Kertész, Vittorio Loreto, Suzy Moat, Jean-Pierre Nadal, Ángel Sánchez, Andrzej Nowak, Andreas Flache, Maxi San Miguel, Dirk Helbing   +13 more
doaj   +1 more source

Applying computational complexity to the emergence of classicality [PDF]

, 2013
Can the computational complexity theory of computer science and mathematics say something new about unresolved problems in quantum physics? Particularly, can the P versus NP question in the computational complexity theory be a factor in the elucidation ...
Bolotin, Arkady
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Special Issue “Computational Social Science”

Information, 2019
The last centuries have seen a great surge in our understanding and control of “simple” physical, chemical, and biological processes through data analysis and the mathematical modeling of their underlying dynamics [...]
Gerardo Iñiguez, Hang-Hyun Jo, Kimmo Kaski   +2 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

CICT: New Eyes on Computational Competence in Computational Science

ITM Web of Conferences, 2018
Science does not exists to enlighten people's minds only. It mainly exists to show the educated way from quanta to qualia. And that way starts from computational competence. In previous papers published elsewhere, we have already shown that traditional Q
Fiorini Rodolfo A.
doaj   +1 more source