Results 51 to 60 of about 1,551,089 (266)

Adaptive nowcasting of influenza outbreaks using Google searches [PDF]

open access: yesRoyal Society Open Science, 2014
Seasonal influenza outbreaks and pandemics of new strains of the influenza virus affect humans around the globe. However, traditional systems for measuring the spread of flu infections deliver results with one or two weeks delay. Recent research suggests
Tobias Preis, Helen Susannah Moat
doaj   +1 more source

Molecular insights into the modulation of the 5HT2A receptor by serotonin, psilocin, and the G protein subunit Gqα

open access: yesFEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.
We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl   +2 more
wiley   +1 more source

Quantifying crowd size with mobile phone and Twitter data [PDF]

open access: yesRoyal Society Open Science, 2015
Being able to infer the number of people in a specific area is of extreme importance for the avoidance of crowd disasters and to facilitate emergency evacuations.
Federico Botta   +2 more
doaj   +1 more source

Attitudes towards Participation in a Passive Data Collection Experiment

open access: yesSensors, 2021
In this paper, we present the results of an exploratory study conducted in Hungary using a factorial design-based online survey to explore the willingness to participate in a future research project based on active and passive data collection via ...
Bence Ságvári   +2 more
doaj   +1 more source

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

open access: yesFEBS Letters, Volume 599, Issue 8, Page 1113-1121, April 2025.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley   +2 more
wiley   +1 more source

Investigation of the Uniformity of Gel Shrinkage by Imaging Tracer Particles Using X‐Ray Microtomography

open access: yesAdvanced Engineering Materials, EarlyView., 2023
A novel method for tracking structural changes in gels using widely accessible microcomputed tomography is presented and validated for various hydro‐, alco‐, and aerogels. The core idea of the method is to track positions of micrometer‐sized tracer particles entrapped in the gel and relate them to the density of the gel network.
Anja Hajnal   +3 more
wiley   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

open access: yesFEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause   +2 more
wiley   +1 more source

GeoAI in Social Science [PDF]

open access: yesHandbook of Spatial Analysis in the Social Sciences, 291 (2022), 2023
GeoAI, or geospatial artificial intelligence, is an exciting new area that leverages artificial intelligence (AI), geospatial big data, and massive computing power to solve problems with high automation and intelligence. This paper reviews the progress of AI in social science research, highlighting important advancements in using GeoAI to fill critical
arxiv  

Ethics and Interdisciplinarity in Computational Social Science

open access: yesMethodological Innovations, 2012
During the last few years a growing amount of content produced by Internet users has become publicly available online. These data come from a variety of places, including popular social web services like Facebook and Twitter, consumer services like ...
Fabio Giglietto, Luca Rossi
doaj   +1 more source

Contribution-Based Grouping under Noise

open access: yesGames, 2017
Many real-world mechanisms are “noisy” or “fuzzy”, that is the institutions in place to implement them operate with non-negligible degrees of imprecision and error.
Heinrich H. Nax   +3 more
doaj   +1 more source

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