Results 61 to 70 of about 109,371 (286)

Analysis of Computational Science Papers from ICCS 2001-2016 using Topic Modeling and Graph Theory [PDF]

, 2017
This paper presents results of topic modeling and network models of topics using the ICCS corpus, which contains domain-specific (computational science) papers over sixteen years (a total of 5695 papers).
Kovalchuk, S.V., Krzhizhanovskaya, V.V., Klavdiya O. Bochenina, Krzhizhanovskaya, V.V.; id_orcid, Lees, M.H., Michael H. Lees, Bochenina, K.O., Abuhay, T.M., George Kampis, Tesfamariam M. Abuhay, Sergey V. Kovalchuk, Kampis, G., Valeria V. Krzhizhanovskaya   +12 more
core   +1 more source

Collective navigation of complex networks: Participatory greedy routing

Scientific Reports, 2017
Many networks are used to transfer information or goods, in other words, they are navigated. The larger the network, the more difficult it is to navigate efficiently.
Kaj-Kolja Kleineberg, Dirk Helbing
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

How voting rules impact legitimacy

Humanities & Social Sciences Communications
Collective action is essential for addressing the grand challenges of our time. However, for such action to be successful, decision-making processes must be perceived as legitimate. In this study, we investigate the legitimacy of different voting methods.
Carina I. Hausladen, Regula Hänggli Fricker, Dirk Helbing, Renato Kunz, Junling Wang, Evangelos Pournaras   +5 more
doaj   +1 more source

Reformulating computational social science with citizen social science: the case of a community-based mental health care research

Humanities & Social Sciences Communications, 2023
Computational social science is being scrutinised and some concerns have been expressed with regards to the lack of transparency and inclusivity in some of the researches.
Isabelle Bonhoure, Anna Cigarini, Julián Vicens, Bàrbara Mitats, Josep Perelló   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Exploring systemic effects of the friendship paradox on social network participation

Applied Network Science
The friendship paradox states that, on average, people have fewer friends than their friends do. This can lead to social perception biases, such as the belief that one’s friends are more socially engaged than oneself.
Ahmed Medhat, Shankar Iyer
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Data through the Computational Lens

, 2017
Today, many advanced studies in computational science are enforced by data collected and processed in distributed systems, obtained and assimilated in real (or near-real) time, used to identify and build models, or even used for advanced visualization to
Dongarra, J., Sloot, P.M.A., Abuhay, T.M., Altintas, I., Kovalchuk, S.V., Krzhizhanovskaya, V.V., Krzhizhanovskaya, V.V.; id_orcid, Norman, M.L., Lees, M.H.   +8 more
core   +1 more source