Results 61 to 70 of about 1,551,089 (266)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

A Large-Scale Community Structure Analysis In Facebook [PDF]

EPJ Data Science, 1:9, 2012, 2011
Understanding social dynamics that govern human phenomena, such as communications and social relationships is a major problem in current computational social sciences. In particular, given the unprecedented success of online social networks (OSNs), in this paper we are concerned with the analysis of aggregation patterns and social dynamics occurring ...
arxiv   +1 more source

A virtual reality experiment to study pedestrian perception of future street scenarios

Scientific Reports
The current allocation of street space is based on expected vehicular peak-hour flows. Flexible and adaptive use of this space can respond to changing needs.
Javier Argota Sánchez-Vaquerizo, Carina I. Hausladen, Sachit Mahajan, Marc Matter, Michael Siebenmann, Michael A. B. van Eggermond, Dirk Helbing   +6 more
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source

Digitize! – Computational Social Science in der digitalen und sozialen Transformation

Zeitschrift für Hochschulentwicklung, 2023
Die Digitalisierung bringt neben vielen Vorteilen für die sozialwissenschaftliche Forschung und die Lehre auch neue Herausforderungen mit sich.
Sylvia Kritzinger, Katharina Pfaff, Julia Barta, Jana Bernhard, Hajo Boomgaarden, Anja Eder, Nikolaus Forgó, Filip Paspalj, Claudia Plant, Barbara Prainsack, Dimitri Prandner, Simon Rittel, Martin Teuffenbach, Sebastian Tschiatschek   +13 more
doaj   +1 more source

Social capital predicts corruption risk in towns [PDF]

Royal Society Open Science, 2019, 2018
Corruption is a social plague: gains accrue to small groups, while its costs are borne by everyone. Significant variation in its level between and within countries suggests a relationship between social structure and the prevalence of corruption, yet, large scale empirical studies thereof have been missing due to lack of data.
arxiv   +1 more source

Thinking spatially in computational social science

EPJ Data Science
Deductive and theory-driven research starts by asking questions. Finding tentative answers to these questions in the literature is next. It is followed by gathering, preparing and modelling relevant data to empirically test these tentative answers ...
Aliakbar Akbaritabar
doaj   +1 more source

Collective navigation of complex networks: Participatory greedy routing

Scientific Reports, 2017
Many networks are used to transfer information or goods, in other words, they are navigated. The larger the network, the more difficult it is to navigate efficiently.
Kaj-Kolja Kleineberg, Dirk Helbing
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source