Results 71 to 80 of about 1,551,089 (266)
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
Mathematical Foundations for Social Computing [PDF]
arXiv, 2020 Social computing encompasses the mechanisms through which people interact with computational systems: crowdsourcing systems, ranking and recommendation systems, online prediction markets, citizen science projects, and collaboratively edited wikis, to name a few.
arxiv
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Artificiality in Social Sciences [PDF]
Rennard, J.-P., Artificiality in Social Sciences, in Rennard,
J.-P. (Ed.), Handbook of Research on Nature Inspired Computing for Economics
and Management, p.1-15, IGR, 2006, 2007 This text provides with an introduction to the modern approach of artificiality and simulation in social sciences. It presents the relationship between complexity and artificiality, before introducing the field of artificial societies which greatly benefited from the computer power fast increase, gifting social sciences with formalization and ...
arxiv
Journal of Social Computing, 2020 Social computing is ubiquitous and intensifying in the 21st Century. Originally used to reference computational augmentation of social interaction through collaborative filtering, social media, wikis, and crowdsourcing, here I propose to expand the ...
James Evans
doaj +1 more source
Digital Health, 2023 Objective In the aging world, the depression of older adults has aroused great concern. It brings detrimental side effects to old adults and the sustainability of society. The information and communication technologies have reshaped how people live among
Chenyang Wang +3 more
doaj +1 more source
Molecular Oncology, Volume 19, Issue 4, Page 1155-1169, April 2025.We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park +8 more
wiley +1 more source
Towards the social media studies of science: social media metrics, present and future [PDF]
Bibliotecas. Anales de Investigacion. 2017. 13(1), 1-5, 2018 In this paper we aim at providing a general reflection around the present and future of social media metrics (or altmetrics) and how they could evolve into a new discipline focused on the study of the relationships and interactions between science and social media, in what could be seen as the social media studies of science.
arxiv
Machine learning in the social and health sciences [PDF]
arXiv, 2021 The uptake of machine learning (ML) approaches in the social and health sciences has been rather slow, and research using ML for social and health research questions remains fragmented. This may be due to the separate development of research in the computational/data versus social and health sciences as well as a lack of accessible overviews and ...
arxiv
How voting rules impact legitimacy
Humanities & Social Sciences CommunicationsCollective action is essential for addressing the grand challenges of our time. However, for such action to be successful, decision-making processes must be perceived as legitimate. In this study, we investigate the legitimacy of different voting methods.
Carina I. Hausladen +5 more
doaj +1 more source