Results 91 to 100 of about 3,869,880 (334)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
wiley   +1 more source

HIV-1 pretreatment and acquired antiretroviral drug resistance before tenofovir/ lamivudine /dolutegravir (TLD) roll-out in Mozambique

BMC Infectious Diseases
Background The World Health Organization (WHO) recommends that HIV treatment scale-up is accompanied by a robust assessment of drug resistance emergence and transmission.
Nália Ismael, Hernane Gemusse, Isabel Mahumane, Osvaldo Laurindo, Cacildo Magul, Cheryl Baxter, Eduan Wilkinson, L. Marije Hofstra, Nick Wagar, Dulce Bila, Nédio Mabunda, Juliana da Silva, Túlio de Oliveira, Elliot Raizes, Wolfgang Preiser, Pedro Manuel, Artur Ramos, Adolfo Vúbil   +17 more
doaj   +1 more source

Enhance Reasoning Ability of Visual-Language Models via Large Language Models [PDF]

arXiv, 2023
Pre-trained visual language models (VLM) have shown excellent performance in image caption tasks. However, it sometimes shows insufficient reasoning ability. In contrast, large language models (LLMs) emerge with powerful reasoning capabilities. Therefore, we propose a method called TReE, which transfers the reasoning ability of a large language model ...
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Computational thinking

Computing Handbook, 3rd ed., 2006
It represents a universally applicable attitude and skill set everyone, not just computer scientists, would be eager to learn and use.
Valerie Barr
semanticscholar   +1 more source

College of education students’ perceptions of their computational thinking proficiency

Frontiers in Education
This study aimed to investigate college of education students’ level of computational thinking proficiency and the differences in their level based on their demographic characteristics, i.e., gender, program, and age.
AlMothana Gasaymeh, Reham AlMohtadi
doaj   +1 more source

Nonequilibrium quantum heat transport between structured environments

New Journal of Physics
We apply the hierarchical equations of motion technique to analyzing nonequilibrium heat transport in a spin-boson type model, whereby heat transfer through a central spin is mediated by an intermediate pair of coupled harmonic oscillators.
Graeme Pleasance, Francesco Petruccione
doaj   +1 more source

Computational Thinking dalam Pembelajaran Matematika Menghadapi Era Society 5.0

Euclid, 2020
Artikel ini mengkaji mengenai kemampuan Computational Thinking sebagai kemampuan esensial Era Society 5.0 dimana digitalisasi artificial intelegence, robotik, otomasi, big data, cyber,  telah menjadi bagian dari aktifitas kehidupan manusia sekaligus ...
Anggita Maharani
doaj   +1 more source