Results 41 to 50 of about 37,180 (284)

Computational Thinking Evaluation Tool Development for Early Childhood Software Education

JOIV: International Journal on Informatics Visualization, 2021
The early childhood software education is being actively conducted, but research on evaluation of computational thinking is in its infancy. The purpose of early childhood software education is to cultivate the computational thinking through activities ...
Kyunghee Lee, Jungwon Cho
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Cosmological constant from canonical transformation in quantum cosmology

Nuclear Physics B
We explore the introduction of the cosmological constant via canonical transformations in cosmology. We consider the Wheeler-DeWitt equation for the cold dark matter (CDM) universe and we construct the Hamilton-Jacobi action for the ΛCDM model, where Λ ...
Andronikos Paliathanasis
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Coding and educational robotics and their relationship with computational and creative thinking. A compressive review.

RED. Revista de Educación a Distancia, 2020
New technological tools, technology-based services and support are being introduced into our daily lives faster than ever. Among these technological advances robotic technology has increased dramatically in recent years, the same as its inclusion in ...
Raidell Avello, Jari Lavonen, Miguel Zapata-Ros   +2 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The “Telephone Game” effect in modern gravity research

European Physical Journal C: Particles and Fields
Triggered by some recent studies within the framework of nonmetricity gravity, I discuss how the basic information regarding the equivalence of the gravitational theories forming the “Trinity of Gravity” has been lost in parts of the literature.
Andronikos Paliathanasis
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Sex classification of 3D skull images using deep neural networks

Scientific Reports
Determining the fundamental characteristics that define a face as "feminine" or "masculine" has long fascinated anatomists and plastic surgeons, particularly those involved in aesthetic and gender-affirming surgery.
Lake Noel, Shelby Chun Fat, Jason L. Causey, Wei Dong, Jonathan Stubblefield, Kathryn Szymanski, Jui-Hsuan Chang, Paul Zhiping Wang, Jason H. Moore, Edward Ray, Xiuzhen Huang   +10 more
doaj   +1 more source

Computational Thinking and Modeling: A Quasi-Experimental Study of Learning Transfer

Education Sciences
This quasi-experimental study investigated the impact of computational learning activities on high school students’ computational thinking (CT) and computational modeling (CM) skills.
Line Have Musaeus, Peter Musaeus
doaj   +1 more source