Results 41 to 50 of about 311,562 (267)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Conserved recombination patterns across hepatitis B genotypes: a retrospective study

Virology Journal
Hepatitis B virus (HBV) infection is a major public health concern, as chronic HBV infection can lead to liver cirrhosis and increase a person’s risk of developing hepatocellular carcinoma (HCC). HBV has been classified into ten genotypes (A to J). Here,
Derek Tshiabuila, James E. San, Eduan Wilkinson, Graeme Dor, Houriiyah Tegally, Tongai G. Maponga, Marion Delphin, Philippa C. Matthews, Darren P. Martin, Cheryl Baxter, Tulio de Oliveira   +10 more
doaj   +1 more source

Research questions and approaches for computational thinking curricula design [PDF]

, 2017
Teaching computational thinking (CT) is argued to be necessary but also admitted to be a very challenging task. The reasons for this, are: i) no general agreement on what computational thinking is; ii) no clear idea nor evidential support on how to teach
Berki , Eleni, Grigoriadou, Kira, Tiensuu , Aleksi, Valtanen , Juri   +3 more
core  

Language as an instrument of thought [PDF]

, 2016
I show that there are good arguments and evidence to boot that support the language as an instrument of thought hypothesis. The underlying mechanisms of language, comprising of expressions structured hierarchically and recursively, provide a perspective (
Akmajian, Asoulin, Bach, Barker, Baronchelli, Berwick, Boeckx, Boeckx, Brattico, Burton-Roberts, Caplan, Carruthers, Cherniak, Cherniak, Cherniak, Cherniak, Cherniak, Chklovskii, Chomsky, Chomsky, Chomsky, Chomsky, Chomsky, Crain, Cummins, Cummins, Cummins, Cummins, Davidson, Davidson, de Waal, Deacon, Di Sciullo, Ding, Dummett, Dummett, Dyer, Ellis, Fitch, Fodor, Fodor, Fodor, Fodor, Fox Keller, Gallistel, Gallistel, Gallistel, Gallistel, Gallistel, Garey, Gauker, Gould, Grice, Grice, Hauser, Hauser, Hauser, Hinzen, Hinzen, Hurford, Jackendoff, Jackendoff, Jackendoff, Jackendoff, Karlsson, Kauffman, Langacker, Lasnik, Leiber, Lenneberg, Mangum, Maynard Smith, McDowell, McLaughlin, Millikan, Moravcsik, Moro, Moro, Origgi, Parker, Petitto, Petitto, Phillips, Phillips, Piantadosi, Piattelli-Palmarini, Pinker, Pinker, Povinelli, Reddy, Reinhart, Reinhart, Roeper, Ross, Ryle, Sauerland, Searle, Semino, Shettleworth, Sigurðsson, Sigurðsson, Simon, Slezak, Smith, Sperber, Sprouse, Stewart, Stromswold, Thompson, Tomalin, Tomasello, Turing, Vanparys, von Humboldt, Walsh, Williams, Yamada, Zwart   +117 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Dolutegravir rollout for treatment of HIV with a focus on advanced disease and tuberculosis coinfection: findings from rural KwaZulu-Natal, South Africa (2019–2023)

AIDS Research and Therapy
Background While Dolutegravir (DTG) containing antiretroviral therapy (ART) has become the preferred regimen for people living with HIV (PLHIV), the pace and equity of its adoption, especially among subgroups with tuberculosis (TB) symptoms and advanced ...
Reuben Christopher Moyo, Larisse Bolton, Elphas Luchemo Okango, Margot Otto, Nthoesele Letoao, Peter Suwirakwenda Nyasulu, Frank Tanser   +6 more
doaj   +1 more source

Peer network approaches for improving HIV testing, prevention and care utilisation among men in sub-Saharan Africa: a scoping review

BMJ Open
Introduction Limited male engagement in HIV prevention and care is a global challenge more pronounced in sub-Saharan Africa (SSA) contributing to ongoing transmission.
Guy Harling, Frank Tanser, Paul Mee, Maxime Inghels, Khai Hoan Tram, Wilfred Ouma Otambo, Margot Otto, Ntombifuthi Blose   +7 more
doaj   +1 more source

Computational Thinking und Kontextorientierung.

Medienimpulse, 2020
Je nach Perspektive wird in der digitalen Bildung über digitale Medien, über Medienbildung, über informationstechnische Grundbildung, über Informatik, Problemlösefähigkeiten, Schlüsselkompetenzen und technische Allgemeinbildung gesprochen.
Michael Steiner, Klaus Himpsl-Gutermann
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Breaking the addition addiction: creating the conditions for knowing-to act in early algebra [PDF]

, 2009
We use data from a teaching experiment with a group of eight years old students to explore the potential of examining number sentences to promote relational thinking.
Ambrose, Rebecca, Castro, Encarnación, Castro, Enrique, Molina, Marta   +3 more
core   +1 more source