Results 121 to 130 of about 2,703,446 (282)

A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents

Toxics
Skin sensitization is a significant concern for chemical safety assessments. Traditional animal assays often fail to predict human responses accurately, and ethical constraints limit the collection of human data, necessitating a need for reliable in ...
Ricardo Scheufen Tieghi, José Teófilo Moreira-Filho, Holli-Joi Martin, James Wellnitz, Miguel Canamary Otoch, Marielle Rath, Alexander Tropsha, Eugene N. Muratov, Nicole Kleinstreuer   +8 more
doaj   +1 more source

In silico toxicology models and databases as FDA Critical Path Initiative toolkits

Human Genomics, 2011
In silico toxicology methods are practical, evidence-based and high throughput, with varying accuracy. In silico approaches are of keen interest, not only to scientists in the private sector and to academic researchers worldwide, but also to the public ...
Valerio Luis G
doaj   +1 more source

Advances in Pharmacological Insights of Borago officinalis: A Comprehensive Review

Biological Diversity, EarlyView.
ABSTRACT Recent growth in phytotherapy and product‐based drug development has increased interest in this plant because of its broad pharmacological activity. This review aims to examine the pharmacological activities, mechanisms, and potential applications of Borago officinalis, focusing on its primary bioactive constituents and therapeutic ...
Zahra Sufwan, Javed Akhtar Ansari, Farogh Ahsan   +2 more
wiley   +1 more source

Co‐cultivation and Medium Optimization: A Strategy for Discovering Fungal‐derived Protease Inhibitors

Chemistry &Biodiversity, EarlyView.
ABSTRACT The fungi Fusarium guttiforme and Phytophthora palmivora were cultivated in four different media (Potato Dextrose Agar, Czapek, rice, and ISP2) and co‐cultured to stimulate fungal interactions and enhance secondary metabolite production. Promising extracts were fractionated, yielding compounds such as the iron complex of fusaric acid (1 ...
Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Adriano Defini Andricopulo, Gisele Barbosa, Renata Krogh, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +7 more
wiley   +1 more source

The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade

Toxics
Environmental exposures are ubiquitous and play a significant, and sometimes understated, role in public health as they can lead to the development of various chronic and infectious diseases. In an ideal world, there would be sufficient experimental data
Siddhi Desai, Jewell Wilson, Chao Ji, Jason Sautner, Andrew J. Prussia, Eugene Demchuk, M. Moiz Mumtaz, Patricia Ruiz   +7 more
doaj   +1 more source

2018 State-of the Science of Dispersants and Dispersed Oil (DDO) in U.S. Arctic Waters: Eco-Toxicity and Sublethal Impacts [PDF]

, 2018
Chemical dispersants were employed on an unprecedented scale during the Deepwater Horizon oil spill in the Gulf of Mexico, and could be a response option should a large spill occur in Arctic waters. The use of dispersants in response to that spill raised
Coastal Response Research Center (CRRC)
core   +1 more source

Discovery of the Postcoital Contraceptive Effect of Rhus pentaphylla in a Study of Acute, Subchronic, and Neurodevelopmental Toxicity of Ethanolic Leaf Extract

Chemistry &Biodiversity, EarlyView.
ABSTRACT In the present study, the acute, subchronic, and neurodevelopmental toxicity of Rhus pentaphylla, a Moroccan medicinal plant, was investigated in Swiss albino mice. HPLC analysis showed the presence of phenolic compounds with rutin as the principal component.
Fatimazahra Agouram, Aicha Ezoubeiri, Abderrahman Chait, Stefania Garzoli, Zahra Sokar   +4 more
wiley   +1 more source

Editorial: Application of computational tools to health and environmental sciences, Volume II

Frontiers in Pharmacology, 2022
Patricia Ruiz, George Loizou
doaj   +1 more source

Toxicity prediction: An application of alternative testing and computational toxicology in contaminated groundwater sites in Taiwan.

Journal of Environmental Management, 2022
Rachelle D. Arcega, Rong Chen, Pei-Shan Chih, Yi-Hsuan Huang, Weiping Chang, Ting Kong, Ching‐Chang Lee, T. Mahmudiono, Chun-Chih Tsui, Wen-Che Hou, H. Hsueh, Hsiu‐Ling Chen   +11 more
semanticscholar   +1 more source

Development of a Novel Aedes aegypti Repellent: An Integrated Approach Combining In Silico and Bioassays

Chemistry &Biodiversity, EarlyView.
OBP1 plays an essential role in the behavior response of Aedes aegypti. The computational approaches employed herein suggest a compound with repellency activity in the ZINC database, which was confirmed by bioassays. ABSTRACT Aedes aegypti is the most important vector of arboviruses, which are responsible for 3.9 billion cases worldwide.
Moysés Fagundes de Araujo Neto, Jânio Rodrigo de Jesus Santos, Ana Luiza Pontes Silva de Oliveira, Antonio Wanderson Vieira Gois, Ingrid Bernardes Santana Martins, Vitor Barbanti Pereira Leite, Adriano Figueiredo Monte Alegre, Jairo Torres Magalhães Junior, Franco Henrique Andrade Leite   +8 more
wiley   +1 more source