Results 121 to 130 of about 73,306 (292)

The Role of Simulation Science in Public Health at the Agency for Toxic Substances and Disease Registry: An Overview and Analysis of the Last Decade

open access: yesToxics
Environmental exposures are ubiquitous and play a significant, and sometimes understated, role in public health as they can lead to the development of various chronic and infectious diseases. In an ideal world, there would be sufficient experimental data
Siddhi Desai   +7 more
doaj   +1 more source

2018 State-of the Science of Dispersants and Dispersed Oil (DDO) in U.S. Arctic Waters: Eco-Toxicity and Sublethal Impacts [PDF]

open access: yes, 2018
Chemical dispersants were employed on an unprecedented scale during the Deepwater Horizon oil spill in the Gulf of Mexico, and could be a response option should a large spill occur in Arctic waters. The use of dispersants in response to that spill raised
Coastal Response Research Center (CRRC)
core   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott   +7 more
wiley   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

open access: yesDrug Testing and Analysis, EarlyView.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes

open access: yesJournal of Translational Medicine
Background Doxorubicin is an important anticancer drug, however, elicits dose-dependently cardiomyopathy. Given its mode of action, i.e. topoisomerase inhibition and DNA damage, we investigated genetic events associated with cardiomyopathy and searched ...
Jürgen Borlak   +6 more
doaj   +1 more source

Statistical Discrimination of Urinary Steroid Biomarkers in the Athlete Biological Passport: A Novel Approach to an Abnormal Steroid Profile Score (ASPS)

open access: yesDrug Testing and Analysis, EarlyView.
The study developed a single Abnormal Steroid Profile Score (ASPS) to improve interpretation of the Athlete Biological Passport steroid module. Using Bayesian modelling and logistic regression, biomarker patterns from laboratory and doping control data successfully discriminated between doped and clean individuals, with improved classification ...
James G. Hopker   +3 more
wiley   +1 more source

Carbon Dots: An Emerging Frontier for Green and Sustainable Civil Engineering Materials

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Traditional civil engineering materials (CE materials) are usually involved with high‐energy consumption during manufacturing, significant maintenance costs, and substantial environmental impacts throughout their life cycles. The progress of nanotechnology is catalyzing a green and sustainable transformation within the field.
Weiwen Hao   +5 more
wiley   +1 more source

A Statistical Exploration of QSAR Models in Cancer Risk Assessment: A Case Study on Pesticide-Active Substances and Metabolites

open access: yesToxics
Data generated using new approach methodologies (NAMs), including in silico, in vitro, and in chemico approaches, are increasingly important for the hazard identification of chemicals.
Serena Greco   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy