Results 11 to 20 of about 72,918 (293)
Scientific Reports, 2022 The treatment of diabetes involves the use of herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract of Persea americana seeds (AEPAS) was explored in this study as a possible therapeutic agent in rats with ...
Oluwafemi Adeleke Ojo +10 more
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Frontiers in Pharmacology, 2022 Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard and ...
Chantel I. Nicolas +10 more
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Systems toxicology: real world applications and opportunities [PDF]
, 2017 Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Amin Rostami-Hodjegan +14 more
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Proteomics for systems toxicology
Computational and Structural Biotechnology Journal, 2014 Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment.
Bjoern Titz +7 more
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High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites
Frontiers in Toxicology, 2023 Introduction: Analysis of streamlined computational models used to predict androgen disrupting chemicals revealed that assays measuring androgen receptor (AR) cofactor recruitment/dimerization were particularly indispensable to high predictivity ...
Evan C. Brown +3 more
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A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity
iScience, 2018 Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale +9 more
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Systems biology and synthetic biology: A new epoch for toxicology research [PDF]
, 2014 Copyright © 2015 Mark T. Mc Auley et al. This is an open access article distributed under the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Choi, Hyunok +4 more
core +7 more sources
Data Quality in Predictive Toxicology: Identification of Chemical Structures and Calculation of Chemical Descriptors [PDF]
, 2000 Every technique for toxicity prediction and for the detection of structure–activity relationships relies on the accurate estimation and representation of chemical and toxicologic properties.
Gottmann, Eva +3 more
core +3 more sources
Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]
, 2017 Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena +9 more
core +1 more source
Computational toxicology using the OpenTox application programming interface and Bioclipse
BMC Research Notes, 2011 Background Toxicity is a complex phenomenon involving the potential adverse effect on a range of biological functions. Predicting toxicity involves using a combination of experimental data (endpoints) and computational methods to generate a set of ...
Willighagen Egon L +4 more
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