Results 191 to 200 of about 3,211,994 (375)

Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment

Frontiers in Pharmacology
N-nitrosamines and nitrosamine drug substance related impurities (NDSRIs) became a critical topic for the development and safety of small molecule medicines following the withdrawal of various pharmaceutical products from the market.
Andreas H. Göller, Sandra Johanssen, Adam Zalewski, Verena Ziegler   +3 more
doaj   +1 more source

Outcome of IWGT workshop on transcriptomic biomarkers for genotoxicity: Key considerations for bioinformatics

Environmental and Molecular Mutagenesis, EarlyView.
Abstract As a part of the International Workshop on Genotoxicity Testing (IWGT) in 2022, a workgroup was formed to evaluate the level of validation and regulatory acceptance of transcriptomic biomarkers that identify genotoxic substances. Several such biomarkers have been developed using various molecular techniques and computational approaches. Within
Matthew J. Meier, Florian Caiment, J. Christopher Corton, Roland Frötschl, Yurika Fujita, Danyel Jennen, Roman Mezencev, Carole Yauk   +7 more
wiley   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Genetic characterization of Staphylococcus aureus isolated from Norway rats in Boston, Massachusetts

Veterinary Medicine and Science, Volume 9, Issue 1, Page 272-281, January 2023., 2023
We identified S. aureus among wild rodents in Boston, MA with antimicrobial resistance genes. Our findings indicate that wild rodents may serve as a under‐studied reservoir of S. aureus and antimicrobial resistance genes with relevance for human exposure and human health.
Gracen R. Gerbig, Helen Piontkivska, Tara C. Smith, Ruairi White, Jean Mukherjee, Hayley Benson, Marieke Rosenbaum, Jessica H. Leibler   +7 more
wiley   +1 more source

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes

Journal of Translational Medicine
Background Doxorubicin is an important anticancer drug, however, elicits dose-dependently cardiomyopathy. Given its mode of action, i.e. topoisomerase inhibition and DNA damage, we investigated genetic events associated with cardiomyopathy and searched ...
Jürgen Borlak, Yari Ciribilli, Alessandra Bisio, Saravanakumar Selvaraj, Alberto Inga, Jung-Hwa Oh, Reinhard Spanel   +6 more
doaj   +1 more source

HyperSBINN: A Hypernetwork-Enhanced Systems Biology-Informed Neural Network for Efficient Drug Cardiosafety Assessment [PDF]

arXiv
Mathematical modeling in systems toxicology enables a comprehensive understanding of the effects of pharmaceutical substances on cardiac health. However, the complexity of these models limits their widespread application in early drug discovery. In this paper, we introduce a novel approach to solving parameterized models of cardiac action potentials by
arxiv  

Quantitative Characterization of Molecular Similarity Spaces: Tools for Computational Toxicology

, 2000
Subnash C. Basak
openalex   +2 more sources

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Porcine antibody profiles of 33 Mycoplasma hyopneumoniae fusion proteins from M. hyopneumoniae natural infection but not vaccination

Veterinary Medicine and Science, Volume 9, Issue 1, Page 203-216, January 2023., 2023
Thirty‐three M. hyopneumoniae fusion proteins were expressed in soluble form. Twenty‐one immunodominant proteins were identified, and six discriminating ones reacted with convalescent but not hyperimmune sera were confirmed. The result provides candidate antigens for the exploration of protective antigens.
Yaru Ning, Yujiao Yang, Yaqin Tian, Yun Zhang, Wenyi Luo, Yukang Wen, Yaoqin Zhou, Honglei Ding   +7 more
wiley   +1 more source

DNA as in‐formation

WIREs Forensic Science, Volume 5, Issue 1, January/February 2023., 2023
Digital forensic technologies change the ways in which DNA is processed as information. Understanding DNA as in‐formation can help us to assess the consequences of this shift. “View of the cell nucleus” by istockphoto. Abstract Traces are fundamental vectors of information.
Mareile Kaufmann
wiley   +1 more source