Results 21 to 30 of about 721,084 (255)

Predicting molecular initiating events using chemical target annotations and gene expression

BioData Mining, 2022
Background The advent of high-throughput transcriptomic screening technologies has resulted in a wealth of publicly available gene expression data associated with chemical treatments.
Joseph L. Bundy, Richard Judson, Antony J. Williams, Chris Grulke, Imran Shah, Logan J. Everett   +5 more
doaj   +1 more source

A harmonized chemical monitoring database for support of exposure assessments

Scientific Data, 2022
Measurement(s) occurrence of chemicals in environmental and biological media Technology Type(s) mass spectrometry (curation of public data) Sample Characteristic - Organism Homo sapiens • aquatic invertebrates • aquatic vertebrates/mammals • birds • fish
Kristin K. Isaacs, Jonathan T. Wall, Ashley R. Williams, Kevin A. Hobbie, Jon R. Sobus, Elin Ulrich, David Lyons, Kathie L. Dionisio, Antony J. Williams, Christopher Grulke, Caroline A. Foster, Josiah McCoy, Charles Bevington   +12 more
doaj   +1 more source

Annotation depth confounds direct comparison of gene expression across species

BMC Bioinformatics, 2021
Background Comparisons of the molecular framework among organisms can be done on both structural and functional levels. One of the most common top-down approaches for functional comparisons is RNA sequencing. This estimation of organismal transcriptional
Elias Oziolor, Seda Arat, Matthew Martin
doaj   +1 more source

Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results

Toxics, 2022
With the abundance of chemicals in the environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays.
Kimberly A. Jarema, Deborah L. Hunter, Bridgett N. Hill, Jeanene K. Olin, Katy N. Britton, Matthew R. Waalkes, Stephanie Padilla   +6 more
doaj   +1 more source

Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods

Frontiers in Pharmacology, 2022
Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard and ...
Chantel I. Nicolas, Matthew W. Linakis, Melyssa S. Minto, Kamel Mansouri, Rebecca A. Clewell, Miyoung Yoon, John F. Wambaugh, Grace Patlewicz, Patrick D. McMullen, Melvin E. Andersen, Harvey J. Clewell III   +10 more
doaj   +1 more source

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

npj Systems Biology and Applications, 2021
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce.
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh   +12 more
doaj   +1 more source

Artificial intelligence as the new frontier in chemical risk assessment

Frontiers in Artificial Intelligence, 2023
The rapid progress of AI impacts various areas of life, including toxicology, and promises a major role for AI in future risk assessments. Toxicology has shifted from a purely empirical science focused on observing chemical exposure outcomes to a data ...
Thomas Hartung, Thomas Hartung
doaj   +1 more source

Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway

Scientific Reports, 2022
The treatment of diabetes involves the use of herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract of Persea americana seeds (AEPAS) was explored in this study as a possible therapeutic agent in rats with ...
Oluwafemi Adeleke Ojo, Jennifer Chidubem Amanze, Abosede Itunuoluwa Oni, Susan Grant, Matthew Iyobhebhe, Tobiloba Christiana Elebiyo, Damilare Rotimi, Nnaemeka Tobechukwu Asogwa, Babatunji Emmanuel Oyinloye, Basiru Olaitan Ajiboye, Adebola Busola Ojo   +10 more
doaj   +1 more source

Systems toxicology: real world applications and opportunities [PDF]

, 2017
Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Amin Rostami-Hodjegan, Coecke S., Gary R. Mirams, Hartung T., Imran Shah, Manuel C. Peitsch, Martin F. Wilks, National Institute of Environmental Health Sciences, OECD, Paul Jennings, Rex E. FitzGerald, Shana J. Sturla, Thomas Hartung, van Vliet E., Wilmes A.   +14 more
core   +2 more sources

Usage of model combination in computational toxicology

Toxicology Letters, 2023
New Approach Methodologies (NAMs) have ushered in a new era in the field of toxicology, aiming to replace animal testing. However, despite these advancements, they are not exempt from the inherent complexities associated with the study's endpoint. In this review, we have identified three major groups of complexities: mechanistic, chemical space, and ...
Rodríguez-Belenguer, Pablo, March-Vila, Eric, Pastor, Manuel, Mangas-Sanjuan, Victor, Soria-Olivas, Emilio   +4 more
openaire   +2 more sources