Results 21 to 30 of about 69,485 (336)
Scientific Reports, 2022 The treatment of diabetes involves the use of herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract of Persea americana seeds (AEPAS) was explored in this study as a possible therapeutic agent in rats with ...
Oluwafemi Adeleke Ojo +10 more
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Artificial intelligence as the new frontier in chemical risk assessment
Frontiers in Artificial Intelligence, 2023 The rapid progress of AI impacts various areas of life, including toxicology, and promises a major role for AI in future risk assessments. Toxicology has shifted from a purely empirical science focused on observing chemical exposure outcomes to a data ...
Thomas Hartung, Thomas Hartung
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Usage of model combination in computational toxicology
Toxicology Letters, 2023 New Approach Methodologies (NAMs) have ushered in a new era in the field of toxicology, aiming to replace animal testing. However, despite these advancements, they are not exempt from the inherent complexities associated with the study's endpoint. In this review, we have identified three major groups of complexities: mechanistic, chemical space, and ...
Rodríguez-Belenguer, Pablo +4 more
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High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites
Frontiers in Toxicology, 2023 Introduction: Analysis of streamlined computational models used to predict androgen disrupting chemicals revealed that assays measuring androgen receptor (AR) cofactor recruitment/dimerization were particularly indispensable to high predictivity ...
Evan C. Brown +3 more
doaj +1 more source
Proteomics for systems toxicology
Computational and Structural Biotechnology Journal, 2014 Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment.
Bjoern Titz +7 more
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Computational Toxicology is Now Inseparable from Experimental Toxicology [PDF]
Alternatives to Laboratory Animals, 2013 Mark T.D. Cronin
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A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity
iScience, 2018 Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale +9 more
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Systems toxicology: real world applications and opportunities [PDF]
, 2017 Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Amin Rostami-Hodjegan +14 more
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Male fathead minnow transcriptomes and associated chemical analytes in the Milwaukee estuary system
Scientific Data, 2022 Measurement(s) transcripts • water chemistry Technology Type(s) RNAseq • GC/MS Factor Type(s) exposure Sample Characteristic - Organism Pimephales promelas Sample Characteristic - Environment estuary system Sample Characteristic - Location Milwaukee, WI,
Natàlia Garcia-Reyero +14 more
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Systems biology and synthetic biology: A new epoch for toxicology research [PDF]
, 2014 Copyright © 2015 Mark T. Mc Auley et al. This is an open access article distributed under the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Choi, Hyunok +4 more
core +6 more sources