Results 61 to 70 of about 721,084 (255)

Antidote application: an educational system for treatment of common toxin overdose [PDF]

, 2017
Poisonings account for almost 1% of emergency room visits each year. Time is a critical factor in dealing with a toxicologic emergency. Delay in dispensing the first antidote dose can lead to life-threatening sequelae.
Brusic, V., Chitkushev, L., Long, J., Zhang, G., Zhang, Y.   +4 more
core  

DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure [PDF]

, 2018
Delayed effects of sulfur mustard (SM) exposure on the levels of five important damage/repair proteins were investigated in 40 SM-exposed veterans of Iran-Iraq war and 35 unexposed controls.
Balali-Mood, Mahdi, Behravan, Effat, Blain, Peter, Jowsey, Paul, Khateri, Shahriar, Sadeghi, Mahmood, Soroush, Mohammad Reza, Williams, Faith   +7 more
core   +2 more sources

Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches

Frontiers in Physiology, 2012
We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. The concept of ‘toxicity pathways’ is described in the context of the 2007 US National Academies of Science report ...
Sudin eBhattacharya, Lisl K.M. Shoda, Qiang eZhang, Courtney eWoods, Brett A. Howell, Scott Q. Siler, Jeffrey L. Woodhead, Yuching eYang, Patrick eMcMullen, Paul B. Watkins, Melvin E. Andersen   +10 more
doaj   +1 more source

Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS)

Toxics
Per- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of PFAS
Katy N. Britton, Richard S. Judson, Bridgett N. Hill, Kimberly A. Jarema, Jeanene K. Olin, Bridget R. Knapp, Morgan Lowery, Madison Feshuk, Jason Brown, Stephanie Padilla   +9 more
doaj   +1 more source

Navigating the bridge between wet and dry lab toxicology research to address current challenges with high-dimensional data

Frontiers in Toxicology, 2023
Toxicology research has rapidly evolved, leveraging increasingly advanced technologies in high-throughput approaches to yield important information on toxicological mechanisms and health outcomes. Data produced through toxicology studies are consequently
Alexis Payton, Alexis Payton, Kyle R. Roell, Kyle R. Roell, Meghan E. Rebuli, Meghan E. Rebuli, Meghan E. Rebuli, William Valdar, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Ilona Jaspers, Julia E. Rager, Julia E. Rager, Julia E. Rager, Julia E. Rager   +15 more
doaj   +1 more source

Hybrid Computational Toxicology Models for Regulatory Risk Assessment [PDF]

, 2015
Computational toxicology is the development of quantitative structure activity relationship (QSAR) models that relate a quantitative measure of chemical structure to a biological effect.
Pradeep, Prachi
core   +1 more source

Network toxicology and its application in studying exogenous chemical toxicity

环境与职业医学
With the continuous development of society, a large number of new chemicals are continuously emerging, which presents a challenge to current risk assessment and safety management of chemicals.
Yanli LIN, Zehua TAO, Zhao XIAO, Chenxu HU, Bobo YANG, Ya WANG, Rongzhu LU   +6 more
doaj   +1 more source

A Similarity Based Approach for Chemical Category Classification [PDF]

, 2005
This report aims to describe the main outcomes of an IHCP Exploratory Research Project carried out during 2005 by the European Chemicals Bureau (Computational Toxicology Action).
GALLEGOS SALINER Ana, TIER GRACE, WORTH ANDREW   +2 more
core  

Correlations between experimental and theoretical adiabatic ionization energies for organic compounds and rate constants for atmospheric reactions with hydroxyl radicals [PDF]

, 2010
Adiabatic ionization energy (AIE) calculations were performed at the AM1, PM3, PM6, PDDG, HF/QZVP, and B3LYP/QZVP levels of theory on 722 atmospherically relevant organic compounds with available experimental rate constants for atmospheric reactions with
Kaya Forest, Sierra Rayne
core   +2 more sources

Modeling and insights into the structural characteristics of drug-induced autoimmune diseases

Frontiers in Immunology, 2022
The incidence and complexity of drug-induced autoimmune diseases (DIAD) have been on the rise in recent years, which may lead to serious or fatal consequences. Besides, many environmental and industrial chemicals can also cause DIAD.
Huizhu Guo, Peitao Zhang, Ruiqiu Zhang, Yuqing Hua, Pei Zhang, Xueyan Cui, Xin Huang, Xiao Li, Xiao Li   +8 more
doaj   +1 more source