Results 11 to 20 of about 22,484 (98)

Numerical Simulation of a High-Speed Impact of Metal Plates Using a Three-Fluid Model

open access: yesMetals, 2021
The process of wave formation at the contact boundary of colliding metal plates is a fundamental basis of explosive welding technology. In this case, the metals are in a pseudo-liquid state at the initial stages of the process, and from a mathematical ...
Petr Chuprov   +2 more
doaj   +1 more source

Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism

open access: yesCell Death and Disease, 2022
Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that displays highly aggressive with poor prognosis. Owing to the limited targets and drugs for TNBC clinical therapy, it is necessary to investigate the factors regulating ...
Pengyun Li   +12 more
doaj   +1 more source

Improving the binding affinity and interaction of 5-Pentyl-2-Phenoxyphenol against Mycobacterium Enoyl ACP reductase by computational approach

open access: yesInformatics in Medicine Unlocked, 2021
Tuberculosis (TB) is one of the leading causes of death worldwide. The development of new anti-tubercular drugs is required as resistant strains of M. tuberculosis to various first-line drugs are currently available.
Jakaria Shawon   +3 more
doaj  

Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-α agents that Target the p38 MAPK Pathway

open access: yesMolecules, 2014
A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-α production in lipopolysaccharide-stimulated THP-1 cells.
Xingzhou Li   +7 more
doaj   +1 more source

Numerical Study of Detonation Wave Propagation in the Variable Cross-Section Channel Using Unstructured Computational Grids

open access: yesJournal of Combustion, 2018
The work is dedicated to the numerical study of detonation wave initiation and propagation in the variable cross-section axisymmetric channel filled with the model hydrogen-air mixture.
Alexander Lopato, Pavel Utkin
doaj   +1 more source

How neocarcerand Octacid4 self-assembles with guests into irreversible noncovalent complexes and what accelerates the assembly

open access: yesCommunications Chemistry, 2022
Neocarcerand Octacid4 can assemble with small molecule guests at room temperature to produce irreversible noncovalent bimolecular complexes, but the nature of the self-assembly pathway remains poorly understood.
Yuan-Ping Pang
doaj   +1 more source

hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties

open access: yesChemistry, 2022
The human ether-a-go-go-related gene (hERG) potassium channel is a well-known contributor to drug-induced cardiotoxicity and therefore is an extremely important target when performing safety assessments of drug candidates.
Himanshu Goel   +2 more
doaj   +1 more source

Industrial Environmental Impact Assessment Method Based on Detection of Complex Anomalies in Time Series

open access: yesApplied System Innovation
To minimize the environmental impact of energy enterprises, it is important to promptly identify cases of possible changes in the quality of wastewater generated at power plants, that is, cases of exceeding the maximum permissible concentrations of ...
Elena Safonova   +5 more
doaj   +1 more source

Identification of the viscoelastic boundary conditions of Euler‐Bernoulli beams using transmissibility

open access: yesEngineering Reports, 2019
A new method to identify the viscoelastic boundary conditions of Euler‐Bernoulli beams under forced response is here presented. The boundary conditions and transmissibility function with viscoelastic expressions in terms of the Green function are ...
Guandong Qiao, Salam Rahmatalla
doaj   +1 more source

Design of a Smart Bartender with Peristaltic Pumps

open access: yesInventions, 2019
In this paper, the development of a smart scalable system for liquid supply based on high-precision peristaltic pumps is described. The architecture of software and hardware for the proposed system is considered. This liquid supply system can be used for
Vyacheslav Rybin   +5 more
doaj   +1 more source

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