Results 21 to 30 of about 1,561,059 (402)

Computer-Aided Design of Antimicrobial Peptides: Are We Generating Effective Drug Candidates?

open access: yesFrontiers in Microbiology, 2020
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely investigated as potential alternatives to antibiotic-based therapies.
M. H. Cardoso   +6 more
semanticscholar   +1 more source

STTG-net: a Spatio-temporal network for human motion prediction based on transformer and graph convolution network

open access: yesVisual Computing for Industry, Biomedicine, and Art, 2022
In recent years, human motion prediction has become an active research topic in computer vision. However, owing to the complexity and stochastic nature of human motion, it remains a challenging problem.
Lujing Chen   +5 more
doaj   +1 more source

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems publication information

open access: yesIEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2020
The IEEE T RANSACTIONS ON C OMPUTER -A IDED D ESIGN OF I NTEGRATED C IRCUITS AND S YSTEMS publishes manuscripts focusing on methods, algorithms, and human-machine interfaces for physical and logical design, including: planning, synthesis, partitioning ...

semanticscholar   +1 more source

Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases

open access: yesInternational Journal of Molecular Sciences, 2021
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need
M. Salman   +5 more
semanticscholar   +1 more source

Determination of critical plane and assessment of fatigue durability for multiaxial cyclic loading and arbitrary shift of phases [PDF]

open access: yesMATEC Web of Conferences, 2019
An analytical solution for the well-known fatigue criterion proposed by Papadopoulos was obtained. An arbitrary shift of phases was taken into account. Comparison between analytical, numerical solutions with experimental data was made.
Stratula Boris A.   +3 more
doaj   +1 more source

VR as a 3D Modelling Tool in Engineering Design Applications

open access: yesApplied Sciences, 2021
The study aims to explore the usefulness of existing VR 3D modelling tools for use in mechanical engineering. Previous studies have investigated the use of VR 3D modelling tools in conceptual phases of the product development process.
Daria Vlah, Vanja Čok, Uroš Urbas
doaj   +1 more source

Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001

open access: yesMolecules, 2016
Ampakine compounds have been shown to reverse opiate-induced respiratory depression by activation of amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors.
Dian Xiao   +6 more
doaj   +1 more source

Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism

open access: yesCell Death and Disease, 2022
Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that displays highly aggressive with poor prognosis. Owing to the limited targets and drugs for TNBC clinical therapy, it is necessary to investigate the factors regulating ...
Pengyun Li   +12 more
doaj   +1 more source

Representation Learning for Sequential Volumetric Design Tasks [PDF]

open access: yes, 2023
Volumetric design, also called massing design, is the first and critical step in professional building design which is sequential in nature. As the volumetric design process requires careful design decisions and iterative adjustments, the underlying sequential design process encodes valuable information for designers.
arxiv   +1 more source

Proxy Design: A Method for Involving Proxy Users to Speak on Behalf of Vulnerable or Unreachable Users in Co-Design [PDF]

open access: yesInformation Technology and People, 2023, 2023
Designing digital artifacts is not a linear, straightforward process. This is particularly true when applying a user-centered design approach, or co-design, with users who are unable to participate in the design process. Although the reduced participation of a particular user group may harm the end result, the literature on solving this issue is sparse.
arxiv   +1 more source

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