Results 31 to 40 of about 1,430,083 (395)

Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-α agents that Target the p38 MAPK Pathway

Molecules, 2014
A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-α production in lipopolysaccharide-stimulated THP-1 cells.
Xingzhou Li, Xinming Zhou, Jing Zhang, Lili Wang, Long Long, Zhibing Zheng, Song Li, Wu Zhong   +7 more
doaj   +1 more source

Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism

Cell Death and Disease, 2022
Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that displays highly aggressive with poor prognosis. Owing to the limited targets and drugs for TNBC clinical therapy, it is necessary to investigate the factors regulating ...
Pengyun Li, Qiaohong Lin, Shiyang Sun, Ning Yang, Yu Xia, Shengjie Cao, Wenjuan Zhang, Qian Li, Haoxin Guo, Maoxiang Zhu, Yilong Wang, Zhibing Zheng, Song Li   +12 more
doaj   +1 more source

Numerical Simulation of a High-Speed Impact of Metal Plates Using a Three-Fluid Model

Metals, 2021
The process of wave formation at the contact boundary of colliding metal plates is a fundamental basis of explosive welding technology. In this case, the metals are in a pseudo-liquid state at the initial stages of the process, and from a mathematical ...
Petr Chuprov, Pavel Utkin, Svetlana Fortova   +2 more
doaj   +1 more source

Numerical Study of Detonation Wave Propagation in the Variable Cross-Section Channel Using Unstructured Computational Grids

Journal of Combustion, 2018
The work is dedicated to the numerical study of detonation wave initiation and propagation in the variable cross-section axisymmetric channel filled with the model hydrogen-air mixture.
Alexander Lopato, Pavel Utkin
doaj   +1 more source

Industrial Environmental Impact Assessment Method Based on Detection of Complex Anomalies in Time Series

Applied System Innovation
To minimize the environmental impact of energy enterprises, it is important to promptly identify cases of possible changes in the quality of wastewater generated at power plants, that is, cases of exceeding the maximum permissible concentrations of ...
Elena Safonova, Alla Kravets, Maxim Shcherbakov, Alexey Kizim, Mohammad Al-Gunaid, Alexander Echin   +5 more
doaj   +1 more source

Computer-aided verification in mechanism design

, 2015
In mechanism design, the gold standard solution concepts are dominant strategy incentive compatibility and Bayesian incentive compatibility. These solution concepts relieve the (possibly unsophisticated) bidders from the need to engage in complicated ...
AV Goldberg, C Daskalakis, EH Clarke, G Barthe, G Barthe, M Bellare, T Groves, T Roughgarden, T Sandholm, W Vickrey   +9 more
core   +4 more sources

How neocarcerand Octacid4 self-assembles with guests into irreversible noncovalent complexes and what accelerates the assembly

Communications Chemistry, 2022
Neocarcerand Octacid4 can assemble with small molecule guests at room temperature to produce irreversible noncovalent bimolecular complexes, but the nature of the self-assembly pathway remains poorly understood.
Yuan-Ping Pang
doaj   +1 more source

Using Computer Technology Tools to Improve the Teaching-Learning Process in Technical and Vocational Education: Mechanical Engineering Subject Area [PDF]

, 2009
This paper discusses the integration of computer assisted instructions (CAI) with traditional class room teaching. It describes a teaching method to bring real-world of industrial work into the classroom that underscores the need to learn fundamental ...
Abdulrasool, Salah Mahdi, Mishra, Rakesh
core   +1 more source

Computer-Aided Design of Microfluidic Circuits.

Annual Review of Biomedical Engineering, 2020
Microfluidic devices developed over the past decade feature greater intricacy, increased performance requirements, new materials, and innovative fabrication methods.
Elishai Ezra Tsur
semanticscholar   +1 more source

Identification of the viscoelastic boundary conditions of Euler‐Bernoulli beams using transmissibility

Engineering Reports, 2019
A new method to identify the viscoelastic boundary conditions of Euler‐Bernoulli beams under forced response is here presented. The boundary conditions and transmissibility function with viscoelastic expressions in terms of the Green function are ...
Guandong Qiao, Salam Rahmatalla
doaj   +1 more source