Results 41 to 50 of about 1,561,059 (402)

hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties

open access: yesChemistry, 2022
The human ether-a-go-go-related gene (hERG) potassium channel is a well-known contributor to drug-induced cardiotoxicity and therefore is an extremely important target when performing safety assessments of drug candidates.
Himanshu Goel   +2 more
doaj   +1 more source

Computer-Aided Design of Microfluidic Circuits.

open access: yesAnnual Review of Biomedical Engineering, 2020
Microfluidic devices developed over the past decade feature greater intricacy, increased performance requirements, new materials, and innovative fabrication methods.
Elishai Ezra Tsur
semanticscholar   +1 more source

Identification of the viscoelastic boundary conditions of Euler‐Bernoulli beams using transmissibility

open access: yesEngineering Reports, 2019
A new method to identify the viscoelastic boundary conditions of Euler‐Bernoulli beams under forced response is here presented. The boundary conditions and transmissibility function with viscoelastic expressions in terms of the Green function are ...
Guandong Qiao, Salam Rahmatalla
doaj   +1 more source

Industrial Environmental Impact Assessment Method Based on Detection of Complex Anomalies in Time Series

open access: yesApplied System Innovation
To minimize the environmental impact of energy enterprises, it is important to promptly identify cases of possible changes in the quality of wastewater generated at power plants, that is, cases of exceeding the maximum permissible concentrations of ...
Elena Safonova   +5 more
doaj   +1 more source

BOgen: Generating Part-Level 3D Designs Based on User Intention Inference through Bayesian Optimization and Variational Autoencoder [PDF]

open access: yesarXiv, 2023
Advancements in generative artificial intelligence (AI) have introduced various AI models capable of producing impressive visual design outputs. However, when it comes to AI models in the design process, prioritizing outputs that align with designers' needs over mere visual craftsmanship becomes even more crucial.
arxiv  

Deep Generative Design: Integration of Topology Optimization and Generative Models [PDF]

open access: yesJournal of Mechanical Design, 141(11), 111405, 2019
Deep learning has recently been applied to various research areas of design optimization. This study presents the need and effectiveness of adopting deep learning for generative design (or design exploration) research area. This work proposes an artificial intelligent (AI)-based design automation framework that is capable of generating numerous design ...
arxiv   +1 more source

Computer-Aided Lipid Design: phase equilibrium modeling for product design [PDF]

open access: yes, 2010
The aim of this work is use phase equilibrium modeling as an auxiliary tool for product design, especially for those whose desired final properties are directly related to solid fat content (SFC) and melting behaviour.
Carrillo Le Roux, Galo   +2 more
core   +1 more source

Computer Aided Plumbing Design [PDF]

open access: yes, 2007
This study has been used to eliminate the rigorous activities and time consuming mathematical analysis involved in Plumbing design. The various mathematical steps employed in the design of plumbing systems has been converted into easily interpreted hand ...
Ajayi, Oluseyi. O, Koya, Olufemi. A
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Design of a Smart Bartender with Peristaltic Pumps

open access: yesInventions, 2019
In this paper, the development of a smart scalable system for liquid supply based on high-precision peristaltic pumps is described. The architecture of software and hardware for the proposed system is considered. This liquid supply system can be used for
Vyacheslav Rybin   +5 more
doaj   +1 more source

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