Results 81 to 90 of about 593,691 (360)

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Improved Adaptive Routing Algorithm in Distributed Data Centers

Advances in Electrical and Electronic Engineering, 2017
Currently, telecom operators use virtualization of network infrastructure based on Data Centers (DCs). But when a company grows to a certain size and one DC is not sufficient, there are questions how to further develop the network infrastructure.
Dmitry Perepelkin, Maria Ivanchikova
doaj   +1 more source

CA-Techniken und CIM [PDF]

, 1991
Der Arbeitsbericht gibt zunächst einen Überblick über die technisch orientierten rechnergestützten Komponenten im Rahmen des Computer Integrated Manufacturing (CIM), die sogenannten CAx-Systeme oder CA-Systeme: CAD (Computer Aided Design) CAP (Computer ...
Kurbel, Karl
core  

The Journal of Computer-Aided Molecular Design: a bibliometric note [PDF]

, 2011
Summarizes the articles in, and the citations to, volumes 2-24 of the Journal of Computer-Aided Molecular Design. The citations to the journal come from almost 2000 different sources that span a very wide range of academic subjects, with the most heavily
Willett, P.
core   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Computer Aided Geometric Design [PDF]

, 1974
Thomas W. Sederberg
openalex   +3 more sources

Grid-based climate variability analysis of Addis Ababa, Ethiopia

Heliyon
Climate change is an intricate global environmental concern. However, its impact is more pervasive in developing nations such as Ethiopia. Hence, this manuscript examines temperature variability and the magnitude of change over 38 years in the specific ...
Esubalew Nebebe Mekonnen, Aramde Fetene, Ephrem Gebremariam   +2 more
doaj   +1 more source

Architectural Limitations in Multi-User Computer-Aided Engineering Applications [PDF]

, 2013
The engineering design process evolves products by a collaborative synthesis of specifications, personnel and organizations. Unfortunately, collaborative effectiveness is thwarted by existing single-user computer-aided applications like computer-aided ...
Benzley, Steven, French, David, Jensen, Greg, Merkley, Karl, Red, Edward, Weerakoon, Prasad   +5 more
core   +2 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source