Results 41 to 50 of about 424,101 (310)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Spatiotemporal Trajectories of Pedestrian Mobility at the Train Station: evidence of 24 million trajectories

Scientific Data
Understanding pedestrian movement remains crucial for designing efficient and safe transportation structures such as terminals, stations, or airports. The significance of conducting a granular analysis in pedestrian mobility dynamics research is evident ...
Tomáš Apeltauer, Ondřej Uhlík, Jiří Apeltauer, Vojtěch Juřík   +3 more
doaj   +1 more source

Analyzing positional accuracy and structural efficiency in additive manufacturing systems with moving elements

Results in Engineering
Simulation is a useful tool for designing and analyzing the characteristics of a system being investigated. In this investigation, modal simulation and harmonic response analysis are performed to predict the dynamic characteristics of an additive ...
Tzu-Chi Chan, Sai Vijay Medarametla, Ratnakar behera   +2 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Effects of incorrect computer-aided detection (CAD) output on human decision-making in mammography [PDF]

, 2004
To investigate the effects of incorrect computer output on the reliability of the decisions of human users. This work followed an independent UK clinical trial that evaluated the impact of computer-aided detection(CAD) in breast screening. The aim was to
Alberdi, E., Ayton, P., Povyakalo, A. A., Strigini, L.   +3 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves [PDF]

, 2009
We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph.
Fu, P., Lueth, T., Meiser, B. M., Reichart, B., Schaefermeier, P. K., Schmitz, C., Sodian, R., Szymanski, D., Weiss, F.   +8 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Molding Characteristics and Impact Strength of Polypropylene with Different Numbers of Recycling Cycles

Engineering Proceedings
We analyzed the changes in the molding properties of polypropylene (PP) resin in the process of recycling after multiple plasticization, injection, and crushing processes.
Hui-Mei Zheng, Jui-Chan Li, Yen-Kai Wang, Kai-Fu Liew, Hsin-Shu Peng   +4 more
doaj   +1 more source