Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Development of a Computer Vision-Based Three-Dimensional Reconstruction Method for Volume-Change Measurement of Unsaturated Soils during Triaxial Testing [PDF]
Problems associated with unsaturated soils are ubiquitous in the U.S., where expansive and collapsible soils are some of the most widely distributed and costly geologic hazards.
Xia, Xiaolong, Zhang, Xiong
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FREE OPEN SOURCE AND SOFTWARE IN THE TEACHING OF CAT TOOLS: OMEGAT, A VIABLE ALTERNATIVE
The teaching of Computer Aided Translation (CAT) tools is essential to all courses aimed at preparing students for the effective exercise of this profession, in particular those students who will translate technical texts, especially in the field of ...
Adauto Lúcio Caetano Villela
doaj +1 more source
Involutions of polynomially parametrized surfaces [PDF]
We provide an algorithm for detecting the involutions leaving a surface defined by a polynomial parametrization invariant. As a consequence, the symmetry axes, symmetry planes and symmetry center of the surface, if any, can be determined directly from ...
Alcázar, J. G., Hermoso, C.
core
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Quelle ergonomie pour la pratique postéditrice des textes traduits ?
Whatever the meaning of post-editing has been over the last 30 years, it has never been looked at from an ergonomic viewpoint. Up to now those who implemented it just wanted to keep translation costs as low as possible and the delays as short as they can.
Louise Brunette, Sharon O’Brien
doaj +1 more source
Retracted: Design and Proofreading of the English-Chinese Computer-Aided Translation System by the Neural Network. [PDF]
Intelligence And Neuroscience C.
europepmc +1 more source
German Translation Teaching Reform Based on Computer Aided Translation Software
Abstract With the rapid development of the times, the role of computer in all aspects of society is becoming more and more obvious, and the translation industry has also been greatly affected. Now the traditional translation no longer meets the requirements of the society, the emergence of computer-supported translation software. Relying
openaire +1 more source

