Results 131 to 140 of about 430,112 (332)

Smart Computer-Aided Translation Environment (SCATE): Highlights

, 2018
We present the highlights of the now finished 4-year SCATE project. It was completed in February 2018 and funded by the Flemish Government IWT-SBO, project No. 130041.
Vandeghinste, Vincent, Vanallemeersch, Tom, Bulté, Bram, Augustinus, Liesbeth, Van Eynde, Frank, Pelemans, Joris, Verwimp, Lyan, Wambacq, Patrick, Heyman, Geert, Moens, Marie-Francine, Lek-Ciudin, Iulianna van der, Steurs, Frieda, Rigouts Terryn, Ayla, Lefever, Els, Tezcan, Arda, Macken, Lieve, Coppers, Sven, Brulmans, Jens, Van den Bergh, Jan, Luyten, Kris, Coninx, Karin   +20 more
openaire   +5 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Carbon Footprint Analysis Model of Computer-aided Translation Products in China: A Perspective From Life Cycle Assessment

SAGE Open
Previous studies have primarily focused on the carbon footprint of physical products, resulting in the oversight of the carbon footprint of digital translation products, particularly the computer-aided translation (CAT) products.
Hong Xie
doaj   +1 more source

Developing Translation Competence of Undergraduate Translation Students under Computer-aided Translation Technology

International Journal on Recent and Innovation Trends in Computing and Communication, 2023
College students who major in translation often face psychological and physiological challenges that affect their learning experience. They have a particular interest in learning translation, but their level is not high; their enthusiasm for translation learning is not high, and they lack confidence.
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Explicitation in translation memory-mediated environments. Methodological conclusions from a pilot study

Translation and Interpreting : the International Journal of Translation and Interpreting Research, 2011
This paper outlines the design and methodological conclusions drawn from a pilot study conducted to measure how translation editing environments impact the presence in translations of one of the most studied translations phenomena: explicitation.
Bartolomé Mesa-Lao
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source