Results 111 to 120 of about 4,605,719 (377)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Computer-assisted design of organic synthesis [PDF]

open access: yes
The computer programs to design synthetic pathways of organic compounds have been utilized throughout the world since the first system was reported by Corey in 1969, and the LHASA was reported in1972 to become the predominant system.
Kaminaka, H.
core   +1 more source

Heteroclinic Connections between Periodic Orbits in Planar Restricted Circular Three Body Problem - A Computer Assisted Proof

open access: yes, 2002
The restricted circular three-body problem is considered for the following parameter values $C=3.03$, $\mu=0.0009537$ - the values for {\em Oterma} comet in the Sun-Jupiter system.
Wilczak, D., Zgliczynski, P.
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Hybrid polymer vessel phantoms for feasibility studies and clinical training of MRI-guided interventions

open access: yesCurrent Directions in Biomedical Engineering, 2022
Gholami Bajestani Denis   +4 more
doaj   +1 more source

Towards a framework for standardized semantic workflow modeling and management in the surgical domain

open access: yesCurrent Directions in Biomedical Engineering, 2015
An essential aspect for workflow management support in operating room environments is the description and visualization of the underlying processes and activities in a machine readable format as Surgical Process Models (SPM).
Neumann Juliane, Neumuth Thomas
doaj   +1 more source

Computer assisted interactive resource scheduling system [PDF]

open access: yes
A computer system is reported that effectively schedules complex mission support by processing spacecraft requirements, station capabilities, and ephemeris data in teletype format ready for ...
Gustafson, C. E.
core   +1 more source

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