Results 61 to 70 of about 109,951 (299)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of Medical Internet Research, 2020 BackgroundAs the COVID-19 epidemic increases in severity, the burden of quarantine stations outside emergency departments (EDs) at hospitals is increasing daily.
Liu, Ping-Yen +12 more
doaj +1 more source
Variable Sociability in Agent-Based Decision Making
, 1999 Multi-agent system research is concerned with the issues surrounding the performance of collections of interacting agents. A major concern, therefore, is with the design of the decision making mechanism that the individual agents employ in order to ...
Jennings, N. R. +5 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Decision Making: A Computer-Science and Information-Technology Viewpoint [PDF]
We address the phenomenon of decision making from the viewpoint of computer science and information technology. The basic question from this viewpoint is: what can the computer offer to decision makers and how it can support their work?
Marko Bohanec
core
A proposed computer-assisted decision making system for the Hellenic Navy decision makers [PDF]
, 1987 The Hellenic Navy currently avoids the use of computers in all functional areas except for routine bookkeeping. Some individual, societal cultural and institutional military factors that influence this attitude are explored. To correct this situation, it
Athanasopoulos, Haralabos
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
The preconditions for computer-assisted decision-making in tomorrow’s schools [PDF]
, 1997 This paper is a summary of a multi-session group discussion among the listed authors in which they deal with three broad questions: What sorts of decisions need to be made in schools? What kinds of computer assistance would be helpful? What are the barriers to obtaining this assistance?
P. Hogenbirk +4 more
openaire +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source