Results 71 to 80 of about 109,951 (299)

Application of context knowledge in supporting conceptual design decision making

, 2010
Conceptual design is the most important phase of the product life cycle as the decisions taken at conceptual design stage affect the downstream phases (manufacture, assembly, use, maintenance, and disposal) in terms of cost, quality and function ...
Xiu Tian Yan, Fayyaz U. Rehman, Yan, Xiu-Tian, Rehman, Fayyaz, Rehman, Fayyaz U.   +4 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development of a novel artificial intelligence algorithm for interpreting fetal heart rate and uterine activity data in cardiotocography

Frontiers in Digital Health
IntroductionCardiotocography (CTG) assesses fetal well-being through measurements of fetal heart rate (FHR) and uterine activity (UA). Manual visual assessment of fetal tracings is variable due to the subjective nature of their interpretation. Artificial
Rohit Pardasani, Renee Vitullo, Sara Harris, Halit O. Yapici, John Beard   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

[Computer-assisted decision-making for trauma patients].

Der Unfallchirurg, 2020
In the management of trauma patients in the resuscitation room many time-pressured and critical decisions must continuously be made in complex situations. Even experienced teams frequently make errors in this context. Computer-assisted decision-making systems can predict critical situations based on patient data continuously acquired online.
Osterhoff G, Pförringer D, Scherer J, Juhra C, Maerdian S, Back DA   +5 more
openaire   +2 more sources

An integrated decision support environment for organisational decision making

, 2008
Traditional decision support systems are based on the paradigm of a single decision maker working at a stand-alone computer or terminal who has a specific decision to make with a specific goal in mind.
Whitfield, R.I., Boyle, Iain M., Duffy, Alex H.B., Duffy, A.H.B., Whitfield, Robert Ian, Liu, Shaofeng, Boyle, I.M.   +6 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Somnolink – a national initiative to improve data sharing for better healthcare and research in obstructive sleep apnea

GMS Medizinische Informatik, Biometrie und Epidemiologie
Introduction: Obstructive sleep apnea (OSA) has a high prevalence and is associated with several severe health conditions. However, it might remain undetected and even when diagnosed, patients show relatively low adherence to the standard therapy ...
Krefting, Dagmar, Arzt, Michael, Brandt, Moritz, Goldammer, Miriam, Ehrlich, Franz, Maurer, Joachim T., Penzel, Thomas, Sehr, Tony, Rodenbeck, Andrea, Zaschke, Philip, Schöbel, Christoph   +10 more
doaj   +1 more source