Results 81 to 90 of about 109,951 (299)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
BMC Medical Informatics and Decision Making, 2018 Background The aim of this study was the development and evaluation of an algorithm-based diagnosis-tool, applicable on mobile phones, to support guardians in providing appropriate care to sick children.
Konstantin H. Franke +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
SEPHYRES 1: A Symptom Checker based on Semantic Pain Descriptors and Weight Spreading
Applied Medical Informatics, 2016 Semantic-enabled medical diagnostic systems, which have exploited an ontology in their internal engines, have failed to perfectly describe disease profiles, especially in complex medical terms having a variant generality level or certainty in the medical
Ali SANAEIFAR +2 more
doaj
Informal Online Decision Making: Current Practices and Support System Design
, 2007 Existing group decision support systems are too complex to support lightweight, informal decision making made popular by the amount of information available on the Web.
André, Paul +2 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
SEPHYRES: A Medical Diagnosis Model based on Semantic Pseudo-Fuzzy Plan and Radar-form Interface
Applied Medical Informatics, 2017 Clinical decision support systems have emerged to help users and patients. Despite the exciting developments, physicians still have not fully accepted and included the decision support systems in daily practice.
Ali SANAEIFAR +4 more
doaj
Evaluation of Building Design Variants in Early Phases on the Basis of Adaptive Detailing Strategies
BuildingsDesign decisions made in the early phases of the design process have a significant impact on the eventual performance of the completed building. Currently, computer-assisted methods offer limited support during the crucial stages of creating, assessing ...
Daniel Napps +12 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source