Results 81 to 90 of about 8,947,674 (288)

Development of a novel artificial intelligence algorithm for interpreting fetal heart rate and uterine activity data in cardiotocography

Frontiers in Digital Health
IntroductionCardiotocography (CTG) assesses fetal well-being through measurements of fetal heart rate (FHR) and uterine activity (UA). Manual visual assessment of fetal tracings is variable due to the subjective nature of their interpretation. Artificial
Rohit Pardasani, Renee Vitullo, Sara Harris, Halit O. Yapici, John Beard   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Somnolink – a national initiative to improve data sharing for better healthcare and research in obstructive sleep apnea

GMS Medizinische Informatik, Biometrie und Epidemiologie
Introduction: Obstructive sleep apnea (OSA) has a high prevalence and is associated with several severe health conditions. However, it might remain undetected and even when diagnosed, patients show relatively low adherence to the standard therapy ...
Krefting, Dagmar, Arzt, Michael, Brandt, Moritz, Goldammer, Miriam, Ehrlich, Franz, Maurer, Joachim T., Penzel, Thomas, Sehr, Tony, Rodenbeck, Andrea, Zaschke, Philip, Schöbel, Christoph   +10 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Imperfections of XAI: Phenomena Influencing AI-Assisted Decision-Making [PDF]

With the increasing use of AI, recent research in human–computer interaction explores Explainable AI (XAI) to make AI advice more interpretable. While research addresses the effects of incorrect AI advice on AI-assisted decision-making, the impact of ...
Perer, Adam, Feng, Michelle, Turri, Violet, Kühl, Niklas, Morrison, Katelyn, Spitzer, Philipp   +5 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A mobile phone based tool to identify symptoms of common childhood diseases in Ghana: development and evaluation of the integrated clinical algorithm in a cross-sectional study

BMC Medical Informatics and Decision Making, 2018
Background The aim of this study was the development and evaluation of an algorithm-based diagnosis-tool, applicable on mobile phones, to support guardians in providing appropriate care to sick children.
Konstantin H. Franke, Ralf Krumkamp, Aliyu Mohammed, Nimako Sarpong, Ellis Owusu-Dabo, Johanna Brinkel, Julius N. Fobil, Axel Bonacic Marinovic, Philip Asihene, Mark Boots, Jürgen May, Benno Kreuels   +11 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

SEPHYRES 1: A Symptom Checker based on Semantic Pain Descriptors and Weight Spreading

Applied Medical Informatics, 2016
Semantic-enabled medical diagnostic systems, which have exploited an ontology in their internal engines, have failed to perfectly describe disease profiles, especially in complex medical terms having a variant generality level or certainty in the medical
Ali SANAEIFAR, Ahmad FARAAHI, Mahmood TARA   +2 more
doaj