Results 81 to 90 of about 271,239 (323)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

El análisis didáctico-tecnológico del proceso de enseñanza-aprendizaje de la Matemática/ The didactic-technological analysis of the teaching-learning process of Mathematics

open access: yesTransformación, 2018
The teaching-learning process of Mathematics is currently undergoing constant changes resulting from the achievements of Information and Communication Technologies, that UNESCO has recognized a priority of the agenda for the Education 2030.
Carmen Fortuna González Trujillo   +2 more
doaj  

Revisión tecnológica del aprendizaje de idiomas asistido por ordenador: una perspectiva cronológica [PDF]

open access: yes, 2019
El presente artículo aborda la evolución y el avance de las tecnologías del aprendizaje de lenguas asistido por ordenador (CALL por sus siglas en inglés, que corresponden a Computer- Assisted Language Learning) desde una perspectiva histórica.
Gómez Parra, María Elena   +2 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Angiographic Anatomy of the Upper and Lower Extremities

open access: yesMedEdPORTAL, 2012
This interactive tutorial serves as an introduction to normal vascular anatomy of the extremities for preclinical medical students. It is composed of high-quality digital subtraction angiography and surface-rendered CT images containing comprehensive ...
Frank D. Reilly   +6 more
doaj   +1 more source

Pembuatan Tutorial Cara Cepat Membaca Dan Berhitung Pada Anak Berbasis Multimedia Menggunakan Macromedia Flash 8 [PDF]

open access: yes, 2016
In the future today children today tend to be interested in playing the game from the study, because the development of the game world is now more rapidly and attractive compared to developments in the world of education, this is what makes children more
Asnawati, A. (Asnawati)   +2 more
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Pediatric Call

open access: yesMedEdPORTAL, 2007
Introduction This is an interactive module tool for third-year medical students rotating through Pediatrics. The objective of this tool is to allow students to experience clinical situations that are required but which may not be available during the ...
Benjamin Estrada
doaj   +1 more source

Using Computer Technology Tools to Improve the Teaching-Learning Process in Technical and Vocational Education: Mechanical Engineering Subject Area [PDF]

open access: yes, 2009
This paper discusses the integration of computer assisted instructions (CAI) with traditional class room teaching. It describes a teaching method to bring real-world of industrial work into the classroom that underscores the need to learn fundamental ...
Abdulrasool, Salah Mahdi, Mishra, Rakesh
core   +1 more source

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