Results 61 to 70 of about 45,251 (264)

Innovative Structural Optimization and Dynamic Performance Enhancement of High-Precision Five-Axis Machine Tools

Journal of Manufacturing and Materials Processing
To satisfy the requirements of five-axis processing quality, this article improves and optimizes the machine tool structure design to produce improved dynamic characteristics. This study focuses on the investigation of five-axis machine tools’ static and
Ratnakar Behera, Tzu-Chi Chan, Jyun-Sian Yang   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Providing Integrated Model of Fuzzy Hierarchical Analysis, Gray Relational Analysis and Multi-Objective Planning for Business Partner Selection [PDF]

چشم‌انداز مدیریت صنعتی, 2011
Today, as the population grows, industries are turning to technologies that can both accelerate production and improve product quality. Computer-aided design, production and engineering is one of the newest technologies used in a wide range of industries
Ali Mohammadi, Mahnaz Hosseinzadeh, Mohammad Bagherzadeh Azar   +2 more
doaj  

Computer-aided engineering and additive manufacturing for bioreactors in tissue engineering: State of the art and perspectives. [PDF]

Biophys Rev (Melville), 2023
Di Gravina GM, Loi G, Auricchio F, Conti M.   +3 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Correcting the Chromatic Aberration in Barrel Distortion of Endoscopic Images [PDF]

Journal of Systemics, Cybernetics and Informatics, 2003
Modern endoscopes offer physicians a wide-angle field of view (FOV) for minimally invasive therapies. However, the high level of barrel distortion may prevent accurate perception of image.
Y. M. Harry Ng, C. P. Kwong
doaj  

Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin. [PDF]

Comput Struct Biotechnol J, 2022
Nikitin D, Mican J, Toul M, Bednar D, Peskova M, Kittova P, Thalerova S, Vitecek J, Damborsky J, Mikulik R, Fleishman SJ, Prokop Z, Marek M.   +12 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Intelligent Support for a Computer Aided Design Optimisation Cycle

Acta Polytechnica, 2006
It is becoming more and more evident that  adding intelligence  to existing computer aids, such as computer aided design systems, can lead to significant improvements in the effective and reliable performance of various engineering tasks, including ...
B. Dolšak, M. Novak, J. Kaljun
doaj