Results 61 to 70 of about 21,987 (211)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
18th CAE Computer Conference [PDF]
, 1987 [Abstract]: Computer Aided Engineering (CAE), the application of computers in the broadest sense including Computer Aided Design (CAD) and Computer Aided Manufacture (CAM), is expected to affect virtually every aspect of engineering.
Hall, David, Toleman, Mark
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Visual Materials - Video - Camp CAEN Computer Exploration Camp
, 2012 Promotional video describing the unique features and course offerings at Camp CAEN, a computer exploration camp for middle and high school students and sponsored by CAEN and the College of Engineering.
Computer-Aided Engineering Network (CAEN), University of Michigan
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30th Symposium on Computer Aided Process Engineering - Part B
, 2020 30th European Symposium on Computer Aided Chemical Engineering, Volume 47 contains the papers presented at the 30th European Symposium of Computer Aided Process Engineering (ESCAPE) event held in Milan, Italy, May 24-27, 2020.
Various Authors +4 more
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FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Modal finite element correlation for computer aided engineering education
Engineering ReportsThe main challenge faced by many mechanical engineering educators is the implementation of real solutions during their courses. One alternative can be a realistic case study, where the students can be engaged in the development and analysis process ...
Moises Jimenez‐Martinez +3 more
doaj +1 more source
Journal of Manufacturing and Materials ProcessingTo satisfy the requirements of five-axis processing quality, this article improves and optimizes the machine tool structure design to produce improved dynamic characteristics. This study focuses on the investigation of five-axis machine tools’ static and
Ratnakar Behera +2 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source