Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Providing Integrated Model of Fuzzy Hierarchical Analysis, Gray Relational Analysis and Multi-Objective Planning for Business Partner Selection [PDF]
چشمانداز مدیریت صنعتی, 2011 Today, as the population grows, industries are turning to technologies that can both accelerate production and improve product quality. Computer-aided design, production and engineering is one of the newest technologies used in a wide range of industries
Ali Mohammadi +2 more
doaj
Computer-aided engineering and additive manufacturing for bioreactors in tissue engineering: State of the art and perspectives. [PDF]
Biophys Rev (Melville), 2023 Di Gravina GM +3 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Correcting the Chromatic Aberration in Barrel Distortion of Endoscopic Images [PDF]
Journal of Systemics, Cybernetics and Informatics, 2003 Modern endoscopes offer physicians a wide-angle field of view (FOV) for minimally invasive therapies. However, the high level of barrel distortion may prevent accurate perception of image.
Y. M. Harry Ng, C. P. Kwong
doaj
Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin. [PDF]
Comput Struct Biotechnol J, 2022 Nikitin D +12 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Intelligent Support for a Computer Aided Design Optimisation Cycle
Acta Polytechnica, 2006 It is becoming more and more evident that adding intelligence to existing computer aids, such as computer aided design systems, can lead to significant improvements in the effective and reliable performance of various engineering tasks, including ...
B. Dolšak, M. Novak, J. Kaljun
doaj
Integrating Taguchi Method and Gray Relational Analysis for Auto Locks by Using Multiobjective Design in Computer-Aided Engineering. [PDF]
Polymers (Basel), 2022 Huang WT, Tasi ZY, Ho WH, Chou JH.
europepmc +1 more source