Results 91 to 100 of about 1,158,587 (297)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Hopes and facts in evaluating the performance of HPC-I/O on a cloud environment

Journal of Computer Science and Technology, 2015
Currently, there is an increasing interest about the cloud platform by the High Performance Computing (HPC) community, and the Parallel I/O for High Performance Systems is not an exception.
Pilar Gómez Sánchez, Sandra Méndez, Dolores Rexachs del Rosario, Emilio Luque   +3 more
doaj  

How blockchain impacts cloud-based system performance: a case study for a groupware communication application [PDF]

, 2019
This paper examines the performance trade-off when implementing a blockchain architecture for a cloud-based groupware communication application. We measure the additional cloud-based resources and performance costs of the overhead required to implement a
Beck, Roman, Eklund, Peter, Spasovski, Jason   +2 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Hardware Trojan Detection in Open-Source Hardware Designs Using Machine Learning

IEEE Access
The globalization of the hardware supply chain reduces costs but increases security challenges with the potential insertion of hardware trojans by third parties.
Victor Takashi Hayashi, Wilson Vicente Ruggiero   +1 more
doaj   +1 more source

MZnet : mail service for personal micro-computer systems [PDF]

, 1984
Traditional computer mail systems involve a co-resident User Agent (UA) and Mail Transfer System (MTS) on a time-shared host computer which may be connected to other hosts ina network, with new mail posted or delivered directly through co-resident mail ...
Domae, Terrance, Stefferud, Einar, Sweet, Jerry   +2 more
core   +1 more source

Photonic architecture for scalable quantum information processing in NV-diamond

, 2013
Physics and information are intimately connected, and the ultimate information processing devices will be those that harness the principles of quantum mechanics. Many physical systems have been identified as candidates for quantum information processing,
Ashley M. Stephens, Burkhard Scharfenberger, Jörg Schmiedmayer, Kae Nemoto, Kathrin Buczak, Mark S. Everitt, Michael Trupke, Simon J. Devitt, Tobias Nöbauer, William J. Munro   +9 more
core   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Multi-computer malware detection systems with metamorphic functionality

Радіоелектронні і комп'ютерні системи
The need to develop new systems for detecting and counteracting malware remains relevant. In addition to malware detection methods, the need to develop new systems for detecting and counteracting malware has become increasingly important.
Antonina Kashtalian, Sergii Lysenko, Oleg Savenko, Andrii Nicheporuk, Tomáš Sochor, Volodymyr Avsiyevych   +5 more
doaj   +1 more source