Results 91 to 100 of about 260,987 (350)

A Classification of Scripting Systems for Entertainment and Serious Computer Games

open access: yes, 2011
The technology base for modern computer games is usually provided by a game engine. Many game engines have built-in dedicated scripting languages that allow the development of complete games that are built using those engines, as well as extensive ...
Anderson, Eike F., Eike Falk Anderson
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Design of Low-Power Neuromorphic Architectures for IoT Applications

open access: yesJournal of Engineering
The rapid growth of the Internet of Things (IoT) demands computing systems that remain highly intelligent while adhering to tight energy constraints. For always-on edge applications, traditional processors are too power-hungry.
Enji Hashim Ismael
doaj   +1 more source

A generic architecture for interactive intelligent tutoring systems

open access: yes, 2001
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 07/06/2001.This research is focused on developing a generic intelligent architecture for an interactive tutoring system.
Atolagbe, T.A.   +1 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Smart Cities: A Systematic Review of Emerging Technologies

open access: yesSmart Cities
In the 21st century, rapid urbanisation has brought both challenges and opportunities. Smart cities have emerged as innovative solutions to meet the complex demands of urban life.
Dante D. Sanchez-Gallegos   +3 more
doaj   +1 more source

Flask : an architecture supporting concurrent distributed persistent applications

open access: yes, 2011
Submitted to BNCOD96 The work was supported by ESPRIT III BRA 6309 — FIDE2 and EPSRC Grant GR/J67611Distributed application systems have become a popular and provenly viable computing paradigm.
Morrison, R.   +5 more
core  

A small and power efficient checkpoint core architecture for manycore processors [PDF]

open access: yes, 2015
This article describes and evaluates a small, out-of-order, simultaneous multithreaded (SMT) core architecture suitable for power constrained microprocessors, such as manycore microprocessors for high performance computing.
Akkary, Haitham H., Sharafeddin, Mageda
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy