Results 81 to 90 of about 260,987 (350)

Quarc: a high-efficiency network on-chip architecture [PDF]

open access: yes, 2009
The novel Quarc NoC architecture, inspired by the Spidergon scheme is introduced as a NoC architecture that is highly efficient in performing collective communication operations including broadcast and multicast.
Vanderbauwhede, Wim   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

An Agent-Based "Virtual Clinical Trial" for the Analysis and Evaluation of COPD Patients Cohorts Behavior

open access: yesJournal of Computer Science and Technology
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory condition characterized by inflammation and narrowing of the airways, leading to symptoms such as shortness of breath, coughing, and chest tightness.
Mohsen Hallaj Asghar   +5 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Gender differences in navigation dialogues with computer systems [PDF]

open access: yes, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Gender is among the most influential of the factors underlying differences in spatial abilities, human communication and interactions with and through ...
Koulouri, Theodora
core  

Dominion : an architecture-driven approach to generating efficient constraint solvers

open access: yes, 2011
This work is supported by the EPSRC grant “A Constraint Solver Synthesiser” (EP/H004092/1) and SICSA studentships.Constraints are used to solve combinatorial problems in a variety of industrial and academic disciplines.
Balasubramaniam, Dharini   +11 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Automating Risk Analysis of Software Design Models

open access: yesThe Scientific World Journal, 2014
The growth of the internet and networked systems has exposed software to an increased amount of security threats. One of the responses from software developers to these threats is the introduction of security activities in the software development ...
Maxime Frydman   +4 more
doaj   +1 more source

Blockchain for healthcare systems: Architecture, security challenges, trends and future directions

open access: yesJournal of Network and Computer Applications, 2023
Andrew Jeyabose Sundar   +5 more
semanticscholar   +1 more source

Using generative programming to visualise hypercode in complex and dynamic systems

open access: yes, 2011
The research presented here takes place in the context of the EC Funded ArchWare project which focuses on innovative architecture-centric languages, frameworks and tools for engineering evolvable software systems.
Balasubramaniam, Dharini   +4 more
core  

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