Results 101 to 110 of about 17,322,096 (306)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Advances in Electrical and Computer Engineering, 2018 This work is the result of a real problem in the Sanitation Company of Espirito Santo (Companhia Espirito Santense de Saneamento), which owns a Geographic Information System, but lacks a mechanism to build routes to server customers that open in ...
MENDES, W. R. +2 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Improved wire memory matrix uses very little power [PDF]
, 1965 Thin-film, plated-wire memory matrix for computer applications requires little power yet has higher speed and four times greater storage capacity than ferrite-core memories of the same ...
Fedde, G. A.
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
A programme to determine the exact interior of any connected digital picture [PDF]
, 2014 Region filling is one of the most important and fundamental operations in computer graphics and image processing. Many filling algorithms and their implementations are based on the Euclidean geometry, which are then translated into computational models ...
Batista, Valério Ramos +1 more
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Applications of computer graphics to aircraft synthesis [PDF]
The history of the development of an aircraft configuration synthesis program using interactive computer graphics was described.
Carmichael, R. L., Putnam, R.
core +1 more source
Computer Algebra Applications for Numerical Relativity [PDF]
, 2003 We discuss the application of computer algebra to problems commonly arising in numerical relativity, such as the derivation of 3+1-splits, manipulation of evolution equations and automatic code generation.
Husa, Sascha, Lechner, Christiane
core +2 more sources