Results 51 to 60 of about 1,373,407 (260)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Techniques for improving reliability of computers [PDF]

, 1972
Modular design techniques improve methods of error detection, diagnosis, and recovery. Theoretical computer (MARCS (Modular Architecture for Reliable Computer Systems)) study deals with postulated and modeled technology indigenous to 1975-1980.
Bouricius, W. G., Cater, W. C., Jessep, D. C., Mccarthy, C. E., Milligan, F. G., Wadia, A. B.   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Generic system architecture for context-aware, distributed recommendation [PDF]

, 2017
In the existing literature on recommender systems, it is difficult to find an architecture for large-scale implementation. Often, the architectures proposed in papers are specific to an algorithm implementation or a domain.
Shah, Neel Harish
core   +1 more source

The architecture of the spherical sky building and its protective role for the Earth Mechanisms for maintaining the hermetic ceiling - the sky - in architecture

Journal of Architecture, Art & Humanistic Science
The sky constitutes an incubating element for the planet Earth that protects it from all the dangers that occur in cosmic space. It can be likened to an outer shell that surrounds the Earth, and it serves as a large envelope or protective ceiling for ...
Dr. Manal Ibrahim Adham Haj Yousef Lecturer at Architecture Department Theba Maadi Academy for Engineering and Computer Science
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Supporting Constructive Learning with a Feedback Planner [PDF]

, 2000
A promising approach to constructing more effective computer tutors is implementing tutorial strategies that extend over multiple turns. This means that computer tutors must deal with (1) failure, (2) interruptions, (3) the need to revise their tactics ...
Core, Mark G., Moore, Johanna, Zinn, Claus   +2 more
core   +2 more sources

BTCP: Binary Temporal Convolutional Network-Based Data Prefetcher for Low Inference Latency and Storage Overhead

IEEE Access
Data prefetching is crucial for hiding long-latency memory access on modern high-performance processors. Machine learning (ML)-based data prefetchers have demonstrated superior address prediction performance compared with traditional rule-based ...
Chang Ho Ryu, Tae Hee Han
doaj   +1 more source

Development Status and Trends of Space Processor

天地一体化信息网络, 2023
Space electronic system is the ＆quot;brain＆quot; of aerospace engineering models and the core fi eld of competitive development of major countries around the world.As the most core device in space electronic system, space processor directly aff ects the ...
Zhigang YU, Xu FENG, Zhou LU, Jixing GAO, Wenhui DING   +4 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source