Results 51 to 60 of about 5,552,920 (364)
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Comparative Analysis of Digital Contact-Tracing Technologies for Informing Public Health Policies
Contact tracing is the cornerstone of epidemic control of infectious diseases, especially in the era of COVID-19. This labor-intensive task calls for the use of digital technology to help identify individuals who have potentially been exposed to the ...
Tsz Ho Kwan
doaj +1 more source
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro+2 more
wiley +1 more source
Energy-Efficient Shared Cache Using Way Prediction Based on Way Access Dominance Detection
To meet the performance demands of chip multiprocessors, chip designers have increased the capacity and hierarchy of cache memories. Accordingly, a shared lower-level cache reduces conflict misses by adopting a multi-way set-associative structure with ...
Yun-Seok Oh, Eui-Young Chung
doaj +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt+8 more
wiley +1 more source
In the Republic of Korea, one of the most widely discussed subjects related to future logistics technology is the drone-based delivery (transportation) system. Much (around 75%) of Korea’s territory consists of mountainous areas; however, the costs
Jun-Ho Huh
doaj +1 more source
Identification of Return-Oriented Programming Attacks Using RISC-V Instruction Trace Data
An increasing number of embedded systems include dedicated neural hardware. To benefit from this specialized hardware, deep learning techniques to discover malware on embedded systems are needed. This effort evaluated candidate machine learning detection
Daniel F. Koranek+3 more
doaj +1 more source
Large-scale modular quantum-computer architecture with atomic memory and photonic interconnects [PDF]
The practical construction of scalable quantum-computer hardware capable of executing nontrivial quantum algorithms will require the juxtaposition of different types of quantum systems.
C. Monroe+6 more
semanticscholar +1 more source
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao+7 more
wiley +1 more source
IoT devices are widely used in the smart home, automobile, and aerospace areas. Note, however, that recent information on thefts and hacking have given rise to many problems.
Seong-Kyu Kim, Ung-Mo Kim, Jun-Ho Huh
doaj +1 more source