Results 81 to 90 of about 5,737,648 (349)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A Study on Improvement of Blockchain Application to Overcome Vulnerability of IoT Multiplatform Security

Energies, 2019
IoT devices are widely used in the smart home, automobile, and aerospace areas. Note, however, that recent information on thefts and hacking have given rise to many problems.
Seong-Kyu Kim, Ung-Mo Kim, Jun-Ho Huh
doaj   +1 more source

Active volume: An architecture for efficient fault-tolerant quantum computers with limited non-local connections [PDF]

, 2022
Daniel Litinski, Naomi Nickerson
openalex   +1 more source

Supporting Constructive Learning with a Feedback Planner [PDF]

, 2000
A promising approach to constructing more effective computer tutors is implementing tutorial strategies that extend over multiple turns. This means that computer tutors must deal with (1) failure, (2) interruptions, (3) the need to revise their tactics ...
Core, Mark G., Moore, Johanna, Zinn, Claus   +2 more
core   +2 more sources

Computer-Aided Diagnosis with Deep Learning Architecture: Applications to Breast Lesions in US Images and Pulmonary Nodules in CT Scans

Scientific Reports, 2016
This paper performs a comprehensive study on the deep-learning-based computer-aided diagnosis (CADx) for the differential diagnosis of benign and malignant nodules/lesions by avoiding the potential errors caused by inaccurate image processing results (e ...
Jie-Zhi Cheng, Dong Ni, Y. Chou, Jing Qin, C. Tiu, Yeun-Chung Chang, Chiun-Sheng Huang, D. Shen, Chung-Ming Chen   +8 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The architecture of the spherical sky building and its protective role for the Earth Mechanisms for maintaining the hermetic ceiling - the sky - in architecture

Journal of Architecture, Art & Humanistic Science
The sky constitutes an incubating element for the planet Earth that protects it from all the dangers that occur in cosmic space. It can be likened to an outer shell that surrounds the Earth, and it serves as a large envelope or protective ceiling for ...
Dr. Manal Ibrahim Adham Haj Yousef Lecturer at Architecture Department Theba Maadi Academy for Engineering and Computer Science
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Improving the Delay of Residue-to-Binary Converter for a Four-Moduli Set

Advances in Electrical and Computer Engineering, 2011
The residue number system (RNS) is an unconventional number system which can be used to achieve high-performance hardware implementations of special-purpose computation systems such as digital signal processors.
MOLAHOSSEINI, A. S.
doaj   +1 more source