Results 81 to 90 of about 266,906 (297)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Aplikasi Perangkat Ajar “Petualangan Fisika” Berbasis Multimedia untuk SMP Kelas 8

ComTech, 2011
Multimedia can be used as a supportive element in education. The most significant implementation of multimedia is shown in computer assisted instruction (CAI).
Fredy Purnomo, Silviana Simidjaja, Dwi Pangestuti, Anggondo Paulus Stifanus   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Angiographic Anatomy of the Upper and Lower Extremities

MedEdPORTAL, 2012
This interactive tutorial serves as an introduction to normal vascular anatomy of the extremities for preclinical medical students. It is composed of high-quality digital subtraction angiography and surface-rendered CT images containing comprehensive ...
Frank D. Reilly, Robert J. Tallaksen, Patricia B. Stoltzfus, Daniel E. Sloan, Penprapa Klinkhachorn, Frank A. Hamilton, Powsiri Klinkhachorn   +6 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Pediatric Call

MedEdPORTAL, 2007
Introduction This is an interactive module tool for third-year medical students rotating through Pediatrics. The objective of this tool is to allow students to experience clinical situations that are required but which may not be available during the ...
Benjamin Estrada
doaj   +1 more source

Scaffolding in Assisted Instruction [PDF]

On-The-Job Training, developed as direct instruction, is one of the earliest forms of training. This method is still widely in use today because it requires only a person who knows how to do the task, and the tools the person uses to do the task.
Gabriel ZAMFIR
core  

Aplikasi Pembelajaran Unified Modeling Language Berbasis Computer Assisted Instruction [PDF]

, 2018
Unified Modeling Language (UML) is one of the important materials in the analysis and design of information systems. UML is used in designing or modeling the system.
Fahmi, Hasanul, Hasdiana, Hasdiana
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

MATERI PELAJARAN INTERAKTIF BAHASA ARAB BERBASIS WEB DAN CD [PDF]

Berbagai terminologi sering digunakan untuk mengungkapkan penggunaan komputer dalam pembelajaran, khususnya pembelajaran bahasa. Masing-masing terminologi memiliki arti berbeda.
Baso, Yusring Sanusi
core