Results 121 to 130 of about 2,694,917 (322)

A local area computer network expert system framework [PDF]

open access: yes
Over the past years an expert system called LANES designed to detect and isolate faults in the Goddard-wide Hybrid Local Area Computer Network (LACN) was developed.
Dominy, Robert
core   +1 more source

Computers, Networks and the Corporation [PDF]

open access: yesScientific American, 1991
Malone, Thomas W., Rockart, John F.
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Development of the analytical model and method of optimization of the priority service corporate computer "Elections" network

open access: yesInformatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
The main objective of this article is to provide recommendations for improving the quality of service indicators in priority service corporate computer networks, including the probability of denial of service attacks, the probability of timely and ...
Zakir Nasib Huseynov
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Network-based malcode detection technology

open access: yesTongxin xuebao, 2007
Following the analysis for traditional distributed IDS,disadvantages that applying structure of multiple engine and small rules set to detect network-level malcode were pointed out,which is based on detailed protocol decoding.Detection model and anti ...
WU Bing1, YUN Xiao-chun2, GAO Qi1
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Bayesian-network-approximate-reasoning-based method for network vulnerabilities evaluation

open access: yesTongxin xuebao, 2008
To evaluate the large-scale computer networks,a Bayesian-network-approximate-reasoning-based method for vulnerabilities evaluation was proposed.First,it models the elements which compose the network and the factors which affect the network security ...
JIA Wei1   +3 more
doaj  

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