Results 131 to 140 of about 10,928,440 (381)

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

A university's educational program in computer science [PDF]

, 1967
George E. Forsythe
openalex   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Exploring Non-Regular Extensions of Propositional Dynamic Logic with Description-Logics Features [PDF]

Logical Methods in Computer Science
We investigate the impact of non-regular path expressions on the decidability of satisfiability checking and querying in description logics extending ALC.
Bartosz Bednarczyk
doaj   +1 more source

Status of computer sciences curricula in colleges and universities [PDF]

, 1964
William F. Atchison, John W. Hamblen
openalex   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

From Computer Science to the Informational Worldview. Philosophical Interpretations of Some Computer Science Concepts

Foundations of Computing and Decision Sciences, 2019
In this article I defend the thesis that modern computer science has a significant philosophical potential, which is expressed in a form of worldview, called here informational worldview (IVW).
Stacewicz Paweł
doaj   +1 more source

Fair Asynchronous Session Subtyping [PDF]

Logical Methods in Computer Science
Session types are widely used as abstractions of asynchronous message passing systems. Refinement for such abstractions is crucial as it allows improvements of a given component without compromising its compatibility with the rest of the system.
Mario Bravetti, Julien Lange, Gianluigi Zavattaro   +2 more
doaj   +1 more source

Information science in a Ph.D. computer science program [PDF]

, 1969
Gerard Salton
openalex   +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source