Results 81 to 90 of about 2,508,631 (310)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Simulation of extreme temperature over Odisha during May 2015

Weather and Climate Extremes, 2017
An extreme temperature event (heat wave) over the state of Odisha was unique as it lasted for about 2 weeks in the 3rd and 4th weeks of May 2015. There was a similar severe heat wave in western and central Odisha in the month of April 1998.
K.C. Gouda, S.K. Sahoo, P. Samantray, S. Himesh   +3 more
doaj   +1 more source

Comparison of the cost‐effectiveness of a computer‐assisted learning program with a tutored demonstration to teach intestinal motility to medical students [PDF]

, 1995
Computer‐based simulations of undergraduate experiments in pharmacology and physiology may offer a cost‐effective alternative to the traditional live laboratory for some students, for whom laboratory skills are less important.
Dewhurst, D. G., Leathard, H. L.
core   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
wiley   +1 more source

Computer simulation of a novel pharmaceutical silicon nanocarrier

Nanotechnology, Science and Applications, 2010
Saeed Soltani, Soroush Sardari, Sima Azadi SororDrug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, IranAbstract: We show the potential of the nanosilicon structure of ...
Saeed Soltani, Soroush Sardar, Sima Azadi Soror   +2 more
doaj  

Optimal control strategy of COVID-19 spread in Morocco using SEIRD model

Moroccan Journal of Pure and Applied Analysis, 2021
This paper aims to predict the development of the COVID-19 pandemic in Morocco from a mathematical approach. Based on the reliability of the data and the nature of confirmed cases, the SEIRD model is employed to provide a theoretical framework to ...
Ferjouchia H., Kouidere A., Zakary O., Rachik M.   +3 more
doaj   +1 more source

Transportation Centrality: Quantifying the Relative Importance of Nodes in Transportation Networks Based on Traffic Modeling

IEEE Access, 2023
The topology of transportation networks such as road and rail networks determines the efficiency and effectiveness of the corresponding transport systems. Quantifying the relative importance of nodes of such networks is vital to understand their dynamics.
Mahendra Piraveenan, Naressa Belle Saripada   +1 more
doaj   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

NeuroTessMesh: A Tool for the Generation and Visualization of Neuron Meshes and Adaptive On-the-Fly Refinement

Frontiers in Neuroinformatics, 2017
Gaining a better understanding of the human brain continues to be one of the greatest challenges for science, largely because of the overwhelming complexity of the brain and the difficulty of analyzing the features and behavior of dense neural networks ...
Juan J. Garcia-Cantero, Juan J. Garcia-Cantero, Juan P. Brito, Juan P. Brito, Susana Mata, Susana Mata, Sofia Bayona, Sofia Bayona, Luis Pastor, Luis Pastor   +9 more
doaj   +1 more source