Results 81 to 90 of about 9,093,329 (381)

The Checking of Computer Logic by Simulation on a Computer [PDF]

The Computer Journal, 1963
The proposed specification of the Sabrac digital computer was first discussed in papers presented to the International Conference on Information Processing (Lehman, 1959) and to the First Annual Conference of the British Computer Society. Since that time the specification of the machine has changed considerably.
Meir M. Lehman, Z. Netter, Rayna Eshed
openaire   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Variational ansatz-based quantum simulation of imaginary time evolution [PDF]

npj Quantum Information, 2018
Imaginary time evolution is a powerful tool for studying quantum systems. While it is possible to simulate with a classical computer, the time and memory requirements generally scale exponentially with the system size.
Sam McArdle, Tyson Jones, Suguru Endo, Ying Li, S. Benjamin, Xiao Yuan   +5 more
semanticscholar   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A Survey of Ocean Simulation and Rendering Techniques in Computer Graphics [PDF]

, 2011
This paper presents a survey of ocean simulation and rendering methods in computer graphics. To model and animate the ocean's surface, these methods mainly rely on two main approaches: on the one hand, those which approximate ocean dynamics with ...
Adabala, Adams, Arvo, Baboud, Becker, Belyaev, Biesel, Bouws, Bridson, Browing, Bruneton, Carlson, Cerezo, Chen, Chen, Chiu, Chou, Clavet, Cui, Darles, Desbrun, Desbrun, Enright, Fang, Finch, Foster, Foster, Foster, Fournier, Frechot, Frish, Gamito, Gonzato, Gonzato, Gordon, Greenwood, Gutierrez, Harlow, Hasselman, Heckbert, Hinsinger, Holmberg, Hong, Hu, Iglesias, Isidoro, Iwasaki, Iwasaki, Iwasaki, Jensen, Jerlov, Jerlov, Jeschke, Johanson, Kass, Kim, Koshizuka, Kryachko, Lachman, Lee, Lee, Lee, Losasso, Losasso, Losasso, Lucy, Mastin, Max, Mihalef, Miller, Mitchell, Monaghan, Morel, Munk, Müller, Müller, Nishita, O’Brien, Peachey, Perez-Cazorla, Pierson, Premoze, Premoze, Radovitzky, Reeves, Robine, Salgado, Schachter, Schlick, Schneider, Solenthaler, Stam, Stora, Takahashi, Terzopoulos, Tessendorf, Thon, Thon, Thon, Thürey, Thürey, Thürey, Tonnesen, Ts’o, Vincent, Wan, Wang, Wang, Watt, Xin, Yan, Yoon, Yu, Yuksel, Zheng   +114 more
core   +4 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Computer simulation of a novel pharmaceutical silicon nanocarrier

Nanotechnology, Science and Applications, 2010
Saeed Soltani, Soroush Sardari, Sima Azadi SororDrug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, IranAbstract: We show the potential of the nanosilicon structure of ...
Saeed Soltani, Soroush Sardar, Sima Azadi Soror   +2 more
doaj  

Toward a first-principles integrated simulation of tokamak edge plasmas [PDF]

, 2008
Performance of the ITER is anticipated to be highly sensitive to the edge plasma condition. The edge pedestal in ITER needs to be predicted from an integrated simulation of the necessary first-principles, multi-scale physics codes.
A Khan, A Kritz, A Pankin, A Shoshani, A Sim, Aymar R, C Docan, C Jin, C Reinhold, C S Chang, Chang C S, D Keyes, D Schultz, D Silver, D Stotler, D Zorin, E D' Azevedo, E Feibush, E Yoon, F Hinton, G Bateman, G Park, Greenwald M, H Abbasi, H Strauss, H Weitzner, J Cummings, J Lofstead, K Bennett, K Schwan, Klasky S, L Greengard, L Sugiyama, Leonard A W, Lofstead J, M Adams, M Nagappan, M Parashar, M Pindzola, M Vouk, M Wolf, N Podhorszki, P Krsti, P Mouallem, P Worley, Park G Y, R Barreto, R Samtaney, S Ethier, S Klasky, S Ku, S Parker, Shoshani A, T Hahm, T Lao, W Lee, Y Chen, Y Xiao, Z Lin   +58 more
core   +1 more source

An adaptive variational algorithm for exact molecular simulations on a quantum computer [PDF]

Nature Communications, 2018
Quantum simulation of chemical systems is one of the most promising near-term applications of quantum computers. The variational quantum eigensolver, a leading algorithm for molecular simulations on quantum hardware, has a serious limitation in that it ...
Harper R. Grimsley, S. Economou, Edwin Barnes, N. Mayhall   +3 more
semanticscholar   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source