Results 71 to 80 of about 1,924,918 (274)

Hacia una definición del Computing Continuum [PDF]

The evolution of the Computing Continuum, coupled with DevOps practices, marks a significant transformation in modern computing. This paper examines the integration of cloud, fog, edge, and IoT technologies to enhance resource utilization, scalability ...
Carrillo, Oscar, Barrios Hernández, Carlos Jaime, Rojas Yepes, Pablo Josue, Le Mouël, Frédéric   +3 more
core   +1 more source

A framework for the predictive monitoring and data quality assurance in the cloud continuum

Journal of Cloud Computing: Advances, Systems and Applications
The widespread adoption of the cloud continuum paradigm poses significant challenges such as the management of heterogeneous infrastructural devices, the strict security and privacy requirements, and the complex data governance constraints.
Lander Bonilla, Josu Diaz-de-Arcaya, Juan López-de-Armentia, Aitor Almeida   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Bridging ACO-Based Drone Logistics and Computing Continuum for Enhanced Smart City Applications

Drones
In the context of evolving Smart Cities, the integration of drone technology and distributed computing paradigms presents significant potential for enhancing urban infrastructure and services.
Salvatore Rosario Bassolillo, Egidio D’Amato, Immacolata Notaro, Luca D’Agati, Giovanni Merlino, Giuseppe Tricomi   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Cognitive Computing Continuum: State-of-the-Art Review and ENACT Vision & Approach

[EN] The evolution from the Edge-Cloud Continuum to the Cognitive Computing Continuum (CCC) has introduced new challenges which necessitate advanced frameworks that integrate cognitive capabilities to enhance interoperability, adaptability, and resource ...
Gabriel Danciu, Karanastasis, Efstathios, Liatifis, Athanasios, Kotsiopoulos, Thanasis, Jarcau, Stefan, Gascón-Repullés, Juan, Campbell, Ross, Drajic, Dejan, Kapetanidou, Ioanna Angeliki, Alexandros Nizamis, Valero-López, Clara Isabel, Khan, Nadia Masood, Mocanu, Vlad, Flor-Damiá, Jaime   +13 more
core   +1 more source