Results 81 to 90 of about 1,924,918 (274)

Resource Allocation Optimization Model for Computing Continuum

Mathematics
The exponential growth of Internet of Things (IoT) devices has led to massive volumes of data, challenging traditional centralized processing paradigms.
Mihaela Mihaiu, Bogdan-Costel Mocanu, Cătălin Negru, Alina Petrescu-Niță, Florin Pop   +4 more
doaj   +1 more source

Statics of Continuum Space Manipulators With Nonconstant Curvature via Pseudorigid-Body 3R Model

IEEE Access, 2018
Continuum space manipulators have wide application prospect in the complex space environment with small space. Efficient and accurate static models are very important for continuum manipulators.
Shaoping Huang, Deshan Meng, Yu She, Xueqian Wang, Bin Liang, Bo Yuan   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Rethinking Computing Systems in the Era of Climate Crisis: A Call for a Sustainable Computing Continuum

The advancement and widespread adoption of computing technology has yielded services that could help mitigate the climate crisis. However, the retirement of obsolete equipment, the consumption of rare earth materials, and the escalating energy demands ...
Incel, Ozlem Durmaz, Waaij, Bram van der, Degeler, Victoria, Peltonen, Ella, Sapra, Dolly, Rellermeyer, Jan S., Bermbach, David, Kjargaard, Mikkel Baun, Leroux, Sam, Riviere, Etienne, Pimentel, Andy D., Mann, Zoltan Adam, Meratnia, Nirvana, Solmaz, Gurkan, Mahmoodi, Toktam, Ding, Aaron Yi, Bayhan, Suzan, Buschjager, Sebastian, Katare, Dewant   +18 more
core   +1 more source

From Technical Prerequisites to Improved Care: Distributed Edge AI for Tomographic Imaging

IEEE Access
Recent years have seen a surge in AI-driven medical image processing, leading to significant improvements in diagnostic performance. However, medical imaging technologies tend to create staggering volumes of medical data, necessitating high-performance ...
Bilgehan Akdemir, Hafiz Faheem Shahid, Mikael A. K. Brix, Juho Laakkola, Johirul Islam, Tanesh Kumar, Jarmo Reponen, Miika T. Nieminen, Erkki Harjula   +8 more
doaj   +1 more source

HPC Parallelisation of Boundary Conditions in Multiscale Methods

Journal of Algorithms & Computational Technology, 2014
This paper investigates two numerical implementations of continuum boundary conditions in parallel high performance computing (HPC) systems in conjunction with multiscale modelling comprising molecular dynamics (MD) and computational fluid dynamics (CFD)
Nikolaos Asproulis, Dimitris Drikakis
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Securing Authentication and Authorization in Computing Continuum

In the era of Computing Continuum, secure and interoperable data sharing across heterogeneous environments is crucial. This research develops innovative cybersecurity components for the computing continuum, integrating the Authentication and Authorization for Constrained Environments (ACE) framework, Ephemeral Diffie-Hellman Over COSE (EDHOC) protocol,
Marín Caballero, Mario, Arias Jiménez, Alejandro, Marin-Perez, Rafael, Skarmeta Gómez, Antonio   +3 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source