Comparison of efficacy of conbercept, aflibercept, and ranibizumab ophthalmic injection in the treatment of macular edema caused by retinal vein occlusion: a Meta-analysis [PDF]
International Journal of Ophthalmology, 2023 AIM: To evaluate and compare the anatomical and functional outcomes and negative effects of the three anti-vascular endothelial growth factor (VEGF) drugs in the treatment of macular edema (ME) due to retinal vein occlusion (RVO) based on the evidence ...
Qiu Xing +3 more
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Structural characterization of a recombinant fusion protein by instrumental analysis and molecular modeling. [PDF]
PLoS ONE, 2013 Conbercept is a genetically engineered homodimeric protein for the treatment of wet age-related macular degeneration (wet AMD) that functions by blocking VEGF-family proteins.
Zhigang Wu +7 more
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Efficacy of conbercept after switching from bevacizumab/ranibizumab in eyes of macular edema secondary to central retinal vein occlusion [PDF]
International Journal of Ophthalmology, 2022 AIM: To explore the efficacy of conbercept after switching from bevacizumab/ranibizumab in eyes of central retinal vein occlusion (CRVO) through optical coherence tomography angiography (OCTA). METHODS: Patients with prior treatment of a minimum of three
Tong Zhao +4 more
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Journal of Ophthalmology, 2021 Objective. This meta-analysis aimed to compare the effect and safety of conbercept with panretinal photocoagulation (PRP) vs. PRP in the treatment of diabetic retinopathy (DR). Methods. Relevant studies were identified through systemic searches of PubMed,
Chao Huang, Haiqing Ji, Xuguang Han
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Frontiers in Medicine, 2021 Background: With the advent of aging society of China, fundus diseases related to pathological neovascularization, including age-related macular degeneration (AMD), diabetic macular edema (DME), and pathological myopia (PM), have become an increasingly ...
Zhuang Cui +7 more
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Conbercept Treatment for Heart-Shaped Vascular Intertwined Nets in Macular Neovascularization: Anti-VEGF Drug Therapy Strategy Based on Vascular Geometry Diagnosed by OCTA. [PDF]
Clin Case RepA 63‐year‐old male with a history of hypertension and diabetes developed acute vision loss, which was attributed to macular neovascularization secondary to hypertensive retinopathy. Optical coherence tomography angiography revealed unusual heart‐shaped, intertwined vascular nets, informing the choice of Conbercept for intravitreal injection.
Ou S, Shi F, Cai M, Wu Y.
europepmc +2 more sources
Conbercept for patients with age-related macular degeneration: a systematic review
BMC Ophthalmology, 2018 Background Conbercept is a novel vascular endothelial growth factor (VEGF) inhibitor for the treatment of wet age-related macular degeneration (AMD). This systematic review aims to assess the efficacy and safety of conbercept in the treatment of wet AMD.
Jiaxing Zhang +7 more
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Cascade-targeted intervention of the NLRP3 inflammasome and downstream angiogenesis by curcumin nanoparticles for ocular neovascularization therapy. [PDF]
Clin Transl MedUltrasound‐microreactor synthesizes monodisperse 125 nm Cur‐NPs with enhanced solubility. Cur‐NPs suppress VEGF signaling and retinal neovascularization via the NLRP3 axis. Multi‐omics profiling reveals that Cur‐NPs reprogram retinal microglia and metabolic pathways.
Jiang S +9 more
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Scientific Reports, 2017 The novel anti-VEGF drug conbercept has been used in the treatment of several retinal neovascular diseases. Owning to the alteration of the structure, the newest drug is capable of combining more molecular targets and present higher affinity to the ...
Jiaming Wang +6 more
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One-year outcomes of intravitreal conbercept combined rescue therapy for polypoidal choroidal vasculopathy in a Chinese population: a real-life clinical data [PDF]
International Journal of Ophthalmology, 2019 AIM: To evaluate the real-life clinical outcomes of intravitreal injection of conbercept combined rescue therapy for polypoidal choroidal vasculopathy (PCV). METHODS: This was an open label, single center, and interventional study. All enrolled patients
Hui-Jun Qi, En-Zhong Jin, Ming-Wei Zhao
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