Results 61 to 70 of about 74,223 (272)

Circular RNAs associated with a mouse model of concanavalin A‐induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis

FEBS Open Bio, 2020
Without treatment, autoimmune hepatitis (AIH) often leads to cirrhosis, liver failure and, in some cases, death. However, the pathogenesis of AIH remains incompletely understood.
Yang Liu, Zhencheng Li, Jianheng Hao, Hao Chen, Tiezheng Hou, Huiqin Hao   +5 more
doaj   +1 more source

The effects of oral administration of Aureobasidium pullulans-cultured fluid containing β-glucan on concanavalin A injected mice

Heliyon, 2021
A black yeast, Aureobasidium pullulans, extracellularly produces β-(1,3), (1,6)-D-glucan (β-glucan) under certain conditions. The β-glucan is known to be an immunomodulatory agent, and β-glucan enriched A.
Zhidan Wang, Kuai Ma, Masayuki Fujino, Kisato Kusano, Shuang-Qin Yi, Atsushi Iwai, Xiao-Kang Li   +6 more
doaj   +1 more source

FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology

Advanced Science, EarlyView.
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou, Yuqing Lv, Lin Li, Shukui Zhang, Jiaqi Liang, Chengchao Wu, Enyu Huang, Jianwei Jiao, Jingjing Zhang   +8 more
wiley   +1 more source

The effect of concanavalin A on the replication of rotavirus (SA-11) in cell culture

Brazilian Archives of Biology and Technology, 2002
Rotavirus (RV) strain SA-11 was studied with respect to its infectivity in MA-104 cell cultures and the effect of concanavalin A (ConA). Receptors for ConA at the surface of MA-104 cell were determined by fluorescence assay and specifically inhibited by ...
Hasenack Beatriz S., Botelho Maria Valéria J., Lauretti Flávio, Melo Fernando L. de, Orlandi Janaina M., Linhares Rosa Elisa C., Ueda Marli, Nozawa Carlos M.   +7 more
doaj  

Concanavalin A disrupts the release of fibrous material necessary for zygote formation of a unicellular charophycean alga, Closterium peracerosum-strigosum-littorale complex

Frontiers in Plant Science, 2016
The Closterium peracerosum–strigosum–littorale (C. psl.) complex is the best characterized charophycean alga with respect to the processes of sexual reproduction.
Jun Abe, Sachie Hori, Mamiko Sato, Hiroyuki Sekimoto, Hiroyuki Sekimoto   +4 more
doaj   +1 more source

Microarray‐based transcriptional profiling of a mouse model of autoimmune hepatitis

FEBS Open Bio, 2020
Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not typically code for a protein. lncRNAs have regulatory roles in many physiological processes, and their dysregulation can contribute to cancer, cardiovascular and ...
Yang Liu, Hao Chen, Jian‐heng Hao, Zhen‐cheng Li, Tiezheng Hou, Hui‐qin Hao   +5 more
doaj   +1 more source

PK/PD Modeling of the PDE7 Inhibitor—GRMS-55 in a Mouse Model of Autoimmune Hepatitis

Pharmaceutics, 2021
This study aimed to assess the efficacy and explore the mechanisms of action of a potent phosphodiesterase (PDE)7A and a moderate PDE4B inhibitor GRMS-55 in a mouse model of autoimmune hepatitis (AIH).
Artur Świerczek, Hanna Plutecka, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa, Elżbieta Wyska   +4 more
doaj   +1 more source

New synchronization method for Plasmodium falciparum [PDF]

, 2010
<b>Background</b>: Plasmodium falciparum is usually asynchronous during in vitro culture. Although various synchronization methods are available, they are not able to narrow the range of ages of parasites.
Abhinav Sinha, C Lambros, EA Nillni, G Pasvol, Georgina S Humphreys, HC Hoppe, J Inselburg, J Lelievre, JA Naughton, JB Jensen, JD Haynes, JD Haynes, JE Mrema, Jonathan M Mwangi, Lisa C Ranford-Cartwright, SB Aley, SY Ahn, W Trager   +17 more
core   +4 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Berbamine and thymoquinone exert protective effects against immune-mediated liver injury via NF-κB dependent pathway

Frontiers in Veterinary Science, 2022
BackgroundImmune-mediated hepatitis is a severe impendence to human health, and no effective treatment is currently available. Therefore, new, safe, low-cost therapies are desperately required.
Sarmed H. Kathem, Waleed K. Abdulsahib, Munaf H. Zalzala   +2 more
doaj   +1 more source