Results 51 to 60 of about 118,548,475 (188)

The effect of concanavalin A on the replication of rotavirus (SA-11) in cell culture

Brazilian Archives of Biology and Technology, 2002
Rotavirus (RV) strain SA-11 was studied with respect to its infectivity in MA-104 cell cultures and the effect of concanavalin A (ConA). Receptors for ConA at the surface of MA-104 cell were determined by fluorescence assay and specifically inhibited by ...
Hasenack Beatriz S., Botelho Maria Valéria J., Lauretti Flávio, Melo Fernando L. de, Orlandi Janaina M., Linhares Rosa Elisa C., Ueda Marli, Nozawa Carlos M.   +7 more
doaj  

Computational insights into the circular permutation roles on ConA binding and structural stability

Current Research in Structural Biology
The mechanisms behind Concanavalin A (ConA) circular permutation have been under investigation since 1985. Although a vast amount of information is available about this lectin and its applications, the exact purpose of its processing remains unclear.
Vinicius J.S. Osterne, Vanir R. Pinto-Junior, Messias V. Oliveira, Kyria S. Nascimento, Els J.M. Van Damme, Benildo S. Cavada   +5 more
doaj   +1 more source

Concanavalin A disrupts the release of fibrous material necessary for zygote formation of a unicellular charophycean alga, Closterium peracerosum-strigosum-littorale complex

Frontiers in Plant Science, 2016
The Closterium peracerosum–strigosum–littorale (C. psl.) complex is the best characterized charophycean alga with respect to the processes of sexual reproduction.
Jun Abe, Sachie Hori, Mamiko Sato, Hiroyuki Sekimoto, Hiroyuki Sekimoto   +4 more
doaj   +1 more source

Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential

Cell Communication and Signaling, 2022
Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular ...
Huldani Huldani, Ahmed Ibraheem Rashid, Khikmatulla Negmatovich Turaev, Maria Jade Catalan Opulencia, Walid Kamal Abdelbasset, Dmitry Olegovich Bokov, Yasser Fakri Mustafa, Moaed E. Al-Gazally, Ali Thaeer Hammid, Mustafa M. Kadhim, Seyed Hossein Ahmadi   +10 more
doaj   +1 more source

Conformational Changes in Concanavalin A

Journal of Biological Chemistry, 1971
Abstract The circular dichroic spectrum of homogeneous concanavalin A shows changes in the near ultraviolet upon specific binding of α-methyl-d-mannoside. The far ultraviolet spectrum shows no evidence of α helical structure but most closely resembles the spectrum of the model for type II-β structure, poly-S-carboxymethyl-l-cysteine.
M N, Pflumm, J L, Wang, G M, Edelman
openaire   +2 more sources

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Extraction and Purification of Laccases from Rice Stems

Bio-Protocol, 2019
Laccases are found in cell walls of plants in very low amounts. This protocol provides an efficient method to purify laccases from rice stems. The method involves three steps: 1) Isolation of total protein from rice stems using buffers with high salt ...
Chenna Swetha, Padubidri Shivaprasad
doaj   +1 more source

AMYLOID FIBRILS FORMATION AND AMORPHOUS AGGREGATION IN CONCANAVALIN A

, 2006
We here report an experimental study on the thermal aggregation process of concanavalin A, a protein belonging to the legume lectins family. The aggregation process and the involved conformational changes of the protein molecules were followed by means ...
VETRI, Valeria, LEONE, Maurizio, F. LIBRIZZI, C. CANALE, M. LEONE, CANALE, Carmelinda, V. VETRI, CANALE, C, RELINI, ANNALISA, GLIOZZI, A, MILITELLO, Valeria, RELINI, A, V. MILITELLO, GLIOZZI, ALESSANDRA, LIBRIZZI, Fabio, Canale C, Librizzi F, Militello V, Relini A, Leone M, Vetri V, Gliozzi A   +21 more
core   +1 more source

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

Advanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song, Hui Yu, Jianping Jiang, Zhihui Jiang, Zhongshi Hong, Xu Zhang, Luchuan Chen, Shenghong Wei, Yi Wang   +8 more
wiley   +1 more source

Efficacy of Concanavalin-A conjugated nanotransfersomal gel of apigenin for enhanced targeted delivery of UV induced skin malignant melanoma

Artificial Cells, Nanomedicine, and Biotechnology, 2019
The aim of present study was to develop the efficient targeting of Concanavalin-A conjugated nanotransfersomal gel to bind directly to melanocytes gel layer against UVB induced skin carcinoma.
Manmohan S. Jangdey, Chanchal Deep Kaur, Swarnlata Saraf   +2 more
doaj   +1 more source