Results 61 to 70 of about 118,548,475 (188)
FEBS Open Bio, 2020 Without treatment, autoimmune hepatitis (AIH) often leads to cirrhosis, liver failure and, in some cases, death. However, the pathogenesis of AIH remains incompletely understood.
Yang Liu +5 more
doaj +1 more source
Protein-carbohydrate interaction , : VI. Isolation of concanavalin a by specific adsorption on cross-linked dextran gels [PDF]
, 1967 1. 1.|A new method is described for the isolation and purification of concanavalin A based on its specific adsorption on cross-linked dextran gels and subsequent displacement with -glucose.2. 2.|The yield of concanavalin A by this method is approx. 2.0-2.
Goldstein, Irwin J. +3 more
core +1 more source
Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation
Advanced Science, EarlyView.Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan +10 more
wiley +1 more source
Microarray‐based transcriptional profiling of a mouse model of autoimmune hepatitis
FEBS Open Bio, 2020 Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not typically code for a protein. lncRNAs have regulatory roles in many physiological processes, and their dysregulation can contribute to cancer, cardiovascular and ...
Yang Liu +5 more
doaj +1 more source
, 1983 Concanavalin A binding sites have been localized on isolated plasma membranes both by a direct technique involving ferritin-concanavalin A and by an indirect technique in which membranes were treated successively with concanavalin A, rabbit anti ...
J V Briggman, C C Widnell
core +1 more source
Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis
Advanced Science, EarlyView.Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He +12 more
wiley +1 more source
Advanced Science, EarlyView.HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu +12 more
wiley +1 more source
Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha +6 more
wiley +1 more source
Journal of Lipid Research, 1977 The interaction of 125I-labeled insulin with purified liver plasma membrane from rats fed a high fat (L) diet or a high glucose (G) diet was studied with respect to specific binding, insulin degradation, binding site degradation, and rate of hormone ...
J V Sun, H M Tepperman, J Tepperman
doaj +1 more source
Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin A
, 2011 We described herein the synthesis of second generation glycopeptide dendrimers G2a-g presenting variable amino acids placed internally into the multivalent scaffold. The effect of such structural modulation on recognition processes by Concanavalin A (Con
Reymond, Jean-Louis +5 more
core +1 more source