Results 41 to 50 of about 34,748 (143)

A comparison of insulin binding by liver plasma membranes of rats fed a high glucose diet or a high fat diet

Journal of Lipid Research, 1977
The interaction of 125I-labeled insulin with purified liver plasma membrane from rats fed a high fat (L) diet or a high glucose (G) diet was studied with respect to specific binding, insulin degradation, binding site degradation, and rate of hormone ...
J V Sun, H M Tepperman, J Tepperman
doaj   +1 more source

The effect of nuclear transcriptional factor κВ activation inhibitor – curcumine on the experimental immune liver disease

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2010
Aim of investigation. To study at two models of immune hepatitis (Т-cellular and antibody origin) in mice damage of the liver, activity and destruction of its immunocompetent cells, thymus gland and the spleen, as well as the effect of curcumine ...
I. N. Alekseyeva, N. V. Makogon, S. I. Pavlovich, T. M. Bryzgina, L. I. Aleksyuk, T. V. Martynova, V. S. Sukhina   +6 more
doaj  

In Vivo Toxicity of Concanavalin A

Experimental Biology and Medicine, 1974
SummaryCon A administered intravenously in doses of 200-800 μg produced atrophy of lymphoid tissues, vascular endothelial damage and focal hepatic necrosis. At the highest dose given, up to 30% of the mice died within two days of what appeared to be acute hepatic failure. The injection of up to 2000 μg Con A ip produced only local inflammatory changes.
openaire   +2 more sources

A Novel Tri-Protein Bio-Interphase Composed of Cytochrome c, Horseradish Peroxidase and Concanavalin A: Electron Transfer and Electrocatalytics

International Journal of Electrochemical Science, 2012
A tri-protein bio-interphase composed of concanavalin A (Con A), cytochrome c (Cyt c) and horseradish peroxidase (HRP) was developed by layer-by-layer assembly of HRP, Con A, mixture of Cyt c and HRP.
Yonghai Song, Yu Wang, Hongyu Liu, Li Wang   +3 more
doaj   +1 more source

Quantitative Proteomic Analysis Reveals That Arctigenin Alleviates Concanavalin A-Induced Hepatitis Through Suppressing Immune System and Regulating Autophagy

Frontiers in Immunology, 2018
Concanavalin A-induced autoimmune hepatitis is a well-established experimental model for immune-mediated liver injury. It has been widely used in the therapeutic studies of immune hepatitis. The in-depth analysis of dysregulated proteins from comparative
Qin Feng, Qin Feng, Jingchun Yao, Ge Zhou, Wenkai Xia, Jingang Lyu, Xin Li, Tao Zhao, Guimin Zhang, Guimin Zhang, Ningwei Zhao, Ningwei Zhao, Jie Yang, Jie Yang   +13 more
doaj   +1 more source

Short-term high-fat diet intake leads to exacerbation of concanavalin A-induced liver injury through the induction of procoagulation state

Biochemistry and Biophysics Reports, 2020
Obesity and high-fat diet (HFD) are known to cause proinflammatory and procoagulation states and suggested to become a risk of developing thromboembolic diseases. Non-alcoholic fatty liver disease (NAFLD) is usually associated with obesity and HFD, and a
Eri Nanizawa, Yuki Tamaki, Reika Sono, Rintaro Miyashita, Yumi Hayashi, Ayumu Kanbe, Hiroyasu Ito, Tetsuya Ishikawa   +7 more
doaj   +1 more source

Derangements of liver tissue bioenergetics in Concanavalin A-induced hepatitis

BMC Gastroenterology, 2013
Background A novel in vitro system was employed to investigate liver tissue respiration (mitochondrial O2 consumption) in mice treated with concanavalin A (Con A).
Al-Shamsi Mariam, Shahin Allen, Mensah-Brown Eric PK, Souid Abdul-Kader   +3 more
doaj   +1 more source

Effect of cholesterol nucleation-promoting activity on cholesterol solubilization in model bile.

Journal of Lipid Research, 1989
Human bile contains a factor with cholesterol nucleation-promoting activity that binds to concanavalin A-Sepharose. In this study we have investigated the effect of this activity on the dynamics of lipid solubilization in supersaturated model bile.
A K Groen, R Ottenhoff, P L Jansen, J van Marle, G N Tytgat   +4 more
doaj   +1 more source

YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response

Genes and Diseases
Severe immune responses regulate the various clinical hepatic injuries, including autoimmune hepatitis and acute viral hepatitis. N6-methyladenosine (m6A) modification is a crucial regulator of immunity and inflammation.
Hao Li, Kailun Yu, Xiandan Zhang, Jiawen Li, Huilong Hu, Xusheng Deng, Siyu Zeng, Xiaoning Dong, Junru Zhao, Yongyou Zhang   +9 more
doaj   +1 more source

Nigella sativa L. Attenuates Oxidative Stress, Inflammation and Apoptosis in Concanavalin A-induced Acute Immunological Liver Damage in Mice

Brazilian Archives of Biology and Technology
Liver’s contribution to innate immunity is eminent. However, uncontrolled inflammatory conditions predispose the liver to immune-mediated injury. Nigella sativa L.
Aqsa Mushtaq, Bilal Aslam, Muhammad Naeem Faisal, Asif Hussain, Sumbul Shamim, Shaneel Kousar, Aneela Gul, Asher Umer   +7 more
doaj   +1 more source