Results 31 to 40 of about 34,748 (143)

Berbamine and thymoquinone exert protective effects against immune-mediated liver injury via NF-κB dependent pathway

open access: yesFrontiers in Veterinary Science, 2022
BackgroundImmune-mediated hepatitis is a severe impendence to human health, and no effective treatment is currently available. Therefore, new, safe, low-cost therapies are desperately required.
Sarmed H. Kathem   +2 more
doaj   +1 more source

The effect of concanavalin A on the replication of rotavirus (SA-11) in cell culture

open access: yesBrazilian Archives of Biology and Technology, 2002
Rotavirus (RV) strain SA-11 was studied with respect to its infectivity in MA-104 cell cultures and the effect of concanavalin A (ConA). Receptors for ConA at the surface of MA-104 cell were determined by fluorescence assay and specifically inhibited by ...
Hasenack Beatriz S.   +7 more
doaj  

Computational insights into the circular permutation roles on ConA binding and structural stability

open access: yesCurrent Research in Structural Biology
The mechanisms behind Concanavalin A (ConA) circular permutation have been under investigation since 1985. Although a vast amount of information is available about this lectin and its applications, the exact purpose of its processing remains unclear.
Vinicius J.S. Osterne   +5 more
doaj   +1 more source

Concanavalin A disrupts the release of fibrous material necessary for zygote formation of a unicellular charophycean alga, Closterium peracerosum-strigosum-littorale complex

open access: yesFrontiers in Plant Science, 2016
The Closterium peracerosum–strigosum–littorale (C. psl.) complex is the best characterized charophycean alga with respect to the processes of sexual reproduction.
Jun Abe   +4 more
doaj   +1 more source

Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential

open access: yesCell Communication and Signaling, 2022
Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular ...
Huldani Huldani   +10 more
doaj   +1 more source

Conformational Changes in Concanavalin A

open access: yesJournal of Biological Chemistry, 1971
Abstract The circular dichroic spectrum of homogeneous concanavalin A shows changes in the near ultraviolet upon specific binding of α-methyl-d-mannoside. The far ultraviolet spectrum shows no evidence of α helical structure but most closely resembles the spectrum of the model for type II-β structure, poly-S-carboxymethyl-l-cysteine.
M N, Pflumm, J L, Wang, G M, Edelman
openaire   +2 more sources

Extraction and Purification of Laccases from Rice Stems

open access: yesBio-Protocol, 2019
Laccases are found in cell walls of plants in very low amounts. This protocol provides an efficient method to purify laccases from rice stems. The method involves three steps: 1) Isolation of total protein from rice stems using buffers with high salt ...
Chenna Swetha, Padubidri Shivaprasad
doaj   +1 more source

Efficacy of Concanavalin-A conjugated nanotransfersomal gel of apigenin for enhanced targeted delivery of UV induced skin malignant melanoma

open access: yesArtificial Cells, Nanomedicine, and Biotechnology, 2019
The aim of present study was to develop the efficient targeting of Concanavalin-A conjugated nanotransfersomal gel to bind directly to melanocytes gel layer against UVB induced skin carcinoma.
Manmohan S. Jangdey   +2 more
doaj   +1 more source

Circular RNAs associated with a mouse model of concanavalin A‐induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis

open access: yesFEBS Open Bio, 2020
Without treatment, autoimmune hepatitis (AIH) often leads to cirrhosis, liver failure and, in some cases, death. However, the pathogenesis of AIH remains incompletely understood.
Yang Liu   +5 more
doaj   +1 more source

Microarray‐based transcriptional profiling of a mouse model of autoimmune hepatitis

open access: yesFEBS Open Bio, 2020
Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that do not typically code for a protein. lncRNAs have regulatory roles in many physiological processes, and their dysregulation can contribute to cancer, cardiovascular and ...
Yang Liu   +5 more
doaj   +1 more source

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