Results 11 to 20 of about 34,748 (143)

Bioinformatic analysis of the interaction between concanavalin A (ConA) from Canavalia ensiformis and the human ALDH18A1 gene in pediatric gastrointestinal cancers with encephalopathy symptoms [PDF]

Journal of HerbMed Pharmacology
Introduction: Pediatric gastrointestinal (GI) cancers with encephalopathy are complex. The role of key genes like ALDH18A1, involved in metabolism and tumorigenesis, remains unclear in these disorders.
Mohammad Hassan Mohammadi, Shima Mohammadkhani, Alaa Sabeeh Alkhazali, Yeganeh Shafiei, Hussein Pour Masoumi, Bahman Fazeli-Nasab   +5 more
doaj   +1 more source

Thymoquinone Attenuates Immune Mediated Liver Injury Induced by Concanavalin A in Mice

Iraqi Journal of Pharmaceutical Sciences, 2021
Autoimmune hepatitis is an inflammatory disease and its incidence has been increasing. The features of hepatitis are the release of inflammatory cytokines, the elevation of AST and ALT, and hepatocyte apoptosis and necrosis.
Halla A. Ahmad, Sarmed H. Kathem
doaj   +1 more source

HEPATOPROTECTIVE EFFECT OF DEFERASIROX IN CONCANAVALIN A-INDUCED ACUTE LIVER INJURY IN RATS [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2016
Hepatitis poses a significant health issue worldwide as it may progress to cirrhosis and hepatocellular carcinoma. The crucial role of liver in different metabolic and synthetic functions of the body stimulates researchers to continually explore and ...
Nada Adel
doaj   +1 more source

Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization

Frontiers in Immunology, 2022
Immune-mediated hepatic injury plays a key role in the initiation and pathogenesis of diverse liver diseases. However, treatment choice for immune-mediated hepatic injury remains limited.
Fenglian Yan, Fenglian Yan, Dalei Cheng, Dalei Cheng, Haiyan Wang, Haiyan Wang, Min Gao, Junfeng Zhang, Junfeng Zhang, Hongyan Cheng, Hongyan Cheng, Changying Wang, Changying Wang, Hui Zhang, Hui Zhang, Huabao Xiong, Huabao Xiong   +16 more
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CP-25 exerts a protective effect against ConA-induced hepatitis via regulating inflammation and immune response

Frontiers in Pharmacology, 2022
Hepatitis is a complex multifactorial pathological disorder, which can eventually lead to liver failure and even potentially be life threatening. Paeoniflorin-6′-O-benzene sulfonate (CP-25) has proven to have critical anti-inflammatory effects in ...
Nan Li, Jing-Jing Wu, Jing-Jing Wu, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Xiu-Qin Li, Ting-Ting Chen, Mei-Fang Wang, Ling-Ling Zhang, Wei Wei, Wu-Yi Sun   +11 more
doaj   +1 more source

Magnesium isoglycyrrhizinate positively affects concanavalin A-induced liver damage by regulating macrophage polarization

Food and Agricultural Immunology, 2018
The deficient functional polarization of macrophages is implicated in the disease progression of autoimmune hepatitis (AIH). This study aims to evaluate the impact of Magnesium isoglycyrrhizinate (MgIG) on concanavalin A (Con A)-induced hepatitis in a ...
Rui Lin, Yun Liu, Meiyu Piao, Yan Song
doaj   +1 more source

MULTIPLEX EVALUATION OF ConA-INDUCED PRODUCTION OF TWELVE CYTOKINES IN THE CULTURES OF MONONUCLEAR CELLS FROM PERIPHERAL BLOOD OF HEALTHY SUBJECTS

Медицинская иммунология, 2014
. The goal of this work was a multiplex single-step evaluation of the levels of stimulated cytokine production in the supernates of cultivated mononuclear cells from healthy Caucasian individuals.
V. I. Konenkov, V. V. Avdoshina, I. G. Rakova, M. V. Smolninkova, E. L. Gelfgat   +4 more
doaj   +1 more source

Concanavalin A Toxicity Towards Potato Psyllid and Apoptosis Induction in Midgut Cells

Insects, 2020
Concanavalin A (ConA), a legume lectin, has been drawing increasing attention in recent years concerning its toxicity against insects and its potential application in pest management.
Xiao-Tian Tang, Freddy Ibanez, Cecilia Tamborindeguy   +2 more
doaj   +1 more source

Construction and function analysis of the LncRNA-miRNA-mRNA competing endogenous RNA network in autoimmune hepatitis

BMC Medical Genomics, 2022
Research Highlights It was the first time to explore the disorder of ceRNA network involved in the pathogenesis of AIH. The co-expression relationship between the differentially expressed lncRNAs, miRNAs and mRNAs were predicted. The potential biological
Zhencheng Li, Ying Liu, Yiwen Hou, Zhurong Li, Chen Chen, Huiqin Hao, Yang Liu   +6 more
doaj   +1 more source

New Insight into the Concanavalin A-Induced Apoptosis in Hepatocyte of an Animal Model: Possible Involvement of Caspase-Independent Pathway

Molecules, 2023
Concanavalin A (Con A) is known to be a T-cell mitogen and has been shown to induce hepatitis in mice through the triggering of conventional T cells and NKT cells.
Xiangli Zhao, Cheng Fu, Lingjuan Sun, Hao Feng, Peiling Xie, Meng Wu, Xiaosheng Tan, Gang Chen   +7 more
doaj   +1 more source