Results 11 to 20 of about 65,297 (230)
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Thymoquinone Attenuates Immune Mediated Liver Injury Induced by Concanavalin A in Mice
Iraqi Journal of Pharmaceutical Sciences, 2021 Autoimmune hepatitis is an inflammatory disease and its incidence has been increasing. The features of hepatitis are the release of inflammatory cytokines, the elevation of AST and ALT, and hepatocyte apoptosis and necrosis.
Halla A. Ahmad, Sarmed H. Kathem
doaj +1 more source
Bioinformatic analysis of the interaction between concanavalin A (ConA) from Canavalia ensiformis and the human ALDH18A1 gene in pediatric gastrointestinal cancers with encephalopathy symptoms [PDF]
Journal of HerbMed PharmacologyIntroduction: Pediatric gastrointestinal (GI) cancers with encephalopathy are complex. The role of key genes like ALDH18A1, involved in metabolism and tumorigenesis, remains unclear in these disorders.
Mohammad Hassan Mohammadi +5 more
doaj +1 more source
Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization
Frontiers in Immunology, 2022 Immune-mediated hepatic injury plays a key role in the initiation and pathogenesis of diverse liver diseases. However, treatment choice for immune-mediated hepatic injury remains limited.
Fenglian Yan +16 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Hepatitis is a complex multifactorial pathological disorder, which can eventually lead to liver failure and even potentially be life threatening. Paeoniflorin-6′-O-benzene sulfonate (CP-25) has proven to have critical anti-inflammatory effects in ...
Nan Li +11 more
doaj +1 more source
Platelet-collagen adhesion: evidence for participation of antigenically distinct entities. [PDF]
, 1984 Univalent antibody fragments prepared from a rabbit antiserum raised against whole human platelets completely inhibited adhesion of platelets to immobilized trimeric collagen in a defined, Mg2+-dependent, adhesion assay.
Barondes, SH, Shadle, PJ
core +2 more sources
BMC Medical Genomics, 2022 Research Highlights It was the first time to explore the disorder of ceRNA network involved in the pathogenesis of AIH. The co-expression relationship between the differentially expressed lncRNAs, miRNAs and mRNAs were predicted. The potential biological
Zhencheng Li +6 more
doaj +1 more source
A Novel Antigen Sensitive to Calcium Chelation That is Associated with the Tip Links and Kinocilial Links of Sensory Hair Bundles [PDF]
, 2003 Tip links are extracellular, cell-surface-associated filaments of unknown molecular composition that are thought to gate the mechanotransducer channel of the sensory hair cell.
Goodyear, Richard J, Richardson, Guy P
core +2 more sources
Медицинская иммунология, 2014 . The goal of this work was a multiplex single-step evaluation of the levels of stimulated cytokine production in the supernates of cultivated mononuclear cells from healthy Caucasian individuals.
V. I. Konenkov +4 more
doaj +1 more source
Molecules, 2023 Concanavalin A (Con A) is known to be a T-cell mitogen and has been shown to induce hepatitis in mice through the triggering of conventional T cells and NKT cells.
Xiangli Zhao +7 more
doaj +1 more source