Results 91 to 100 of about 9,774,757 (278)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Does bank concentration lead to concentration in industrial sectors? [PDF]
This paper explores the effect of banking market structure on the market structure of industrial sectors. It asks whether concentration in the banking market promotes the formation of industries constituted by a few, large firms, or rather, whether it ...
Nicola Cetorelli
core
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
O trabalho teve como objetivo avaliar a resposta de crisântemo através da análise de parâmetros fenométricos, ao redutor de crescimento Daminozide, pulverizado na cultivar de crisântemo de corte "Snowdon", cultivada em vaso. O estudo foi formado por dois
Jucelma de Cássia Câmara Tolotti +2 more
doaj +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Behavioral Determinants of Childhood Obesity in the United States: An Exploratory Study
Childhood obesity is a complex and multifactorial phenomenon. Understanding these factors is crucial in developing effective interventions to prevent and treat childhood obesity.
Soumitra Palit +4 more
doaj +1 more source
Elemental composition of thalli of the lichen Cladоnia stellaris under air pollution
The elemental composition of Cladonia lichens in areas affected by the Murmansk Region metal processing industry was investigated. Abnormally high levels of heavy metals (Cu, Ni, Fe) were detected in lichens under this impact.
Tatyana Sukhareva
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Solar technology offers great potential in terms of supplying the world's energy needs. However, its current contribution to the world is still limited. The main factor is related to high initial cost of building the system. This paper will provide an up-to-date review of solar concentrators and their benefits to make solar technology affordable.
Muhammad-Sukki, Firdaus +4 more
openaire +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source

